HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

gamma chain CD3 antigen

Also Known As:

CD3 antigen, gamma chain; CD3gamma

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Differentiation Antigens: 2082
    - T-Lymphocyte Differentiation Antigens: 40
      - CD3 Complex: 147
        gamma chain CD3 antigen: 8
- Antigens: 143924
  - Surface Antigens: 5813
    - Differentiation Antigens: 2082
      - T-Lymphocyte Differentiation Antigens: 40
        CD3 Complex: 147
        gamma chain CD3 antigen: 8

Experts

1.	Burny, Arsène: 3 articles (09/2007 - 12/2002)
2.	Willard-Gallo, Karen E: 3 articles (09/2007 - 12/2002)
3.	Chen, Shaohua: 2 articles (05/2011 - 01/2011)
4.	Li, Yangqiu: 2 articles (05/2011 - 01/2011)
5.	Yang, Lijian: 2 articles (05/2011 - 01/2011)
6.	Martiat, Philippe: 2 articles (09/2007 - 10/2005)
7.	Badran, Bassam M: 2 articles (10/2005 - 12/2002)
8.	Chen, Si: 1 article (05/2011)
9.	Du, Xin: 1 article (05/2011)
10.	Geng, Suxia: 1 article (05/2011)

Related Diseases

1.	Infections 09/06/2007 - "In uninfected and cells immediately post-infection all three DHS sites were open, then the CD3gamma promoter became non accessible, and this was followed by a sequential closure of all the DHS sites corresponding to all three transcriptional control regions. " 12/06/2002 - "Our data show that the loss of CD3gamma transcripts begins very early after infection and accumulates to a >90% deficiency before a significant effect on surface receptor density is apparent. " 12/06/2002 - "Finally, we have shown that an increase in the binding of nuclear NFATc2, NFATc1, and NF-kappaB p50 to these three motifs is correlated with a progressive loss of CD3gamma transcripts after HIV-1 infection." 12/06/2002 - "Human immunodeficiency virus, type 1 (HIV-1) infection of CD4(+) T cells progressively abrogates T cell receptor (TCR).CD3 function and surface expression by specifically interfering with CD3gamma gene transcription. "
2.	Type 1 Hyper-IgM Immunodeficiency Syndrome 12/01/2000 - "Currently 14 registries are distributed, including information about Bloom syndrome (BLMbase), X-linked agammaglobulinemia (BTKbase), X-linked and autosomal recessive chronic granulomatous diseases (CYBBbase for X-linked CGD, CYBAbase for p22(phox) deficiency, NCF1base for p47(phox) deficiency, NCF2base for p67(phox) deficiency), CD3gamma and CD3epsilon deficiencies (CD3Gbase, CD3Ebase), X-linked hyper-IgM syndrome (CD40Lbase), T-B+ severe combined immunodeficiency (JAK3base), V(D)J recombination defects (RAG1base, RAG2base), X-linked lymphoproliferative syndrome (SH2D1Abase), and ZAP-70 deficiency (ZAP70base). "
3.	Hypereosinophilic Syndrome (Loeffler Endocarditis) 10/01/2005 - "Defective CD3gamma gene transcription is associated with NFATc2 overexpression in the lymphocytic variant of hypereosinophilic syndrome." 10/01/2005 - "Hypereosinophilic syndrome joins the growing number of pathological conditions where a defect in surface expression and/or function of the TCR/CD3 complex results from altered regulation of CD3gamma gene expression."
4.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 12/01/2000 - "Currently 14 registries are distributed, including information about Bloom syndrome (BLMbase), X-linked agammaglobulinemia (BTKbase), X-linked and autosomal recessive chronic granulomatous diseases (CYBBbase for X-linked CGD, CYBAbase for p22(phox) deficiency, NCF1base for p47(phox) deficiency, NCF2base for p67(phox) deficiency), CD3gamma and CD3epsilon deficiencies (CD3Gbase, CD3Ebase), X-linked hyper-IgM syndrome (CD40Lbase), T-B+ severe combined immunodeficiency (JAK3base), V(D)J recombination defects (RAG1base, RAG2base), X-linked lymphoproliferative syndrome (SH2D1Abase), and ZAP-70 deficiency (ZAP70base). "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2011 - "In order to elucidate the feature of T-cell receptor (TCR) signal transduction in T-cells from acute myeloid leukemia (AML), the expression levels of CD3gamma, delta, epsilon and zeta chain genes in CD3+ T cells were analyzed using real-time PCR. "

Related Drugs and Biologics

1.	T-Cell Antigen Receptors (T-Cell Receptor)
2.	T-Cell Antigen Receptor-CD3 Complex
3.	NF-kappa B (NF-kB)
4.	Deoxyribonuclease I (Nickase)
5.	Creatinine
6.	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)