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stellettin B

from the marine sponge Rhabdastrella globostellata; structure in first source

Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - stellettin B: 10

Experts

1.	Jin, Meihua: 3 articles (04/2017 - 07/2014)
2.	Kong, Dexin: 3 articles (04/2017 - 07/2014)
3.	Qiu, Yuling: 3 articles (04/2017 - 07/2014)
4.	Wang, Ran: 3 articles (04/2017 - 07/2014)
5.	Zhong, Yuxu: 2 articles (04/2017 - 01/2016)
6.	Zhou, Qianxiang: 2 articles (04/2017 - 07/2014)
7.	Chen, Bing-Hung: 1 article (02/2019)
8.	Chen, Nan-Fu: 1 article (02/2019)
9.	Chen, Wu-Fu: 1 article (02/2019)
10.	Cheng, Shu-Yu: 1 article (02/2019)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 02/14/2019 - "We discovered that stellettin B reduces migration of glioblastoma cells by scratch wound healing assay and invasion via chamber transwell assay. " 07/15/2014 - "Stellettin B exhibited highly potent inhibition against the growth of a human glioblastoma cell line SF295, with a GI50 of 0.01 μM. " 02/14/2019 - "This study further demonstrates that stellettin B affects filamentous actin (F-actin) rearrangement by decreasing the cross-linkage of phosphor-Girdin (p-Girdin), which attenuates glioblastoma cell invasion. " 01/01/2023 - "Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair." 01/01/2023 - "Stellettin B Sensitizes Glioblastoma to DNA-Damaging Treatments by Suppressing PI3K-Mediated Homologous Recombination Repair."
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "In this study, we used Stellettin B, an active compound isolated from Stelletta sponges, as the experimental drug and evaluated its inhibition effects on cell migration and invasion in human hepatoma cells (HA22T and HepG2). " 01/01/2022 - "Stellettin B Isolated from Stelletta Sp. Reduces Migration and Invasion of Hepatocellular Carcinoma Cells through Reducing Activation of the MAPKs and FAK/PI3K/AKT/mTOR Signaling Pathways."
3.	Neoplasms (Cancer) 07/15/2014 - "In contrast, stellettin B showed very weak inhibitory activity on normal cell lines including HMEC, RPTEC, NHBE and PrEC, with GI50s higher than 10 μM, suggesting its relatively selective cytotoxicity against human cancer cells compared to normal human cell lines. " 02/01/2002 - "Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively." 02/14/2019 - "Overall, we conclude that stellettin B might be a potential antiangiogenic and anti-invasion agent for future development of therapeutic agents for cancer therapy." 07/15/2014 - "In vitro antitumor activity of stellettin B, a triterpene from marine sponge Jaspis stellifera, on human glioblastoma cancer SF295 cells."
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 04/25/2017 - "Stellettin B induces apoptosis in human chronic myeloid leukemia cells via targeting PI3K and Stat5."
5.	Mouth Neoplasms (Oral Cancer) 08/08/2022 - "Stellettin B-Induced Oral Cancer Cell Death via Endoplasmic Reticulum Stress-Mitochondrial Apoptotic and Autophagic Signaling Pathway."

Related Drugs and Biologics

1.	Actins (F Actin)
2.	Triterpenes
3.	Death-Associated Protein Kinases
4.	TOR Serine-Threonine Kinases
5.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	DNA (Deoxyribonucleic Acid)
8.	Poly(ADP-ribose) Polymerase Inhibitors

Related Therapies and Procedures

1.	Therapeutics