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gantacurium

Neuromuscular Depolarizing Agents; structure in first source

Also Known As:

GW 280430A; GW-280430A; GW280430A

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - gantacurium: 4

Experts

1.	Savarese, John J: 2 articles (04/2010 - 04/2004)
2.	Campoy, Luis: 1 article (03/2015)
3.	Cheetham, Jonathan: 1 article (03/2015)
4.	Gleed, Robin D: 1 article (03/2015)
5.	Heerdt, Paul M: 1 article (03/2015)
6.	Martin-Flores, Manuel: 1 article (03/2015)
7.	Sakai, Daniel M: 1 article (03/2015)
8.	Emala, Charles W: 1 article (04/2010)
9.	Sunaga, Hiroshi: 1 article (04/2010)
10.	Zhang, Yi: 1 article (04/2010)

Related Diseases

1.	Flushing 04/01/2004 - "The ratio ED Hist:ED95 Neuromuscular Block in the monkey was significantly greater (approximately 53 vs. 13) for GW280430A, indicating approximately four times less relative prominence of the side effects of skin flushing and decrease of blood pressure, which are associated with release of histamine. "
2.	Paralysis (Palsy) 04/01/2010 - "These findings suggest that gantacurium and CW002 are devoid of significant effects at airway muscarinic receptors particularly M3 receptors on bronchial smooth musculature at doses several fold higher than those required for functional muscle paralysis."
3.	Laryngismus (Laryngospasm) 03/01/2015 - "Laryngospasm was elicited in all cats at baseline, after administration of 0.1mg of gantacurium/kg, and after the effects of the last dose of gantacurium had terminated. " 03/01/2015 - "The 0.3 and 0.5 mg/kg doses of gantacurium abolished laryngospasm in 3 and 8 cats, respectively, and induced complete neuromuscular block measured at the pelvic limb; the mean ± SE duration of apnea was 2 ± 1 minutes and 3 ± 1.5 minutes, respectively. " 03/01/2015 - "Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats." 03/01/2015 - "To evaluate whether the ultrashort-acting neuromuscular blocking agent gantacurium can be used to blunt evoked laryngospasm in anesthetized cats and to determine the duration of apnea without hemoglobin desaturation. "
4.	Dehydration (Water Stress) 03/02/2002 - "GW280430A undergoes dehydration at 40 degrees C, glass transition at 130 degrees C and decomposition at 190 degrees C by differential scanning calorimetry. "
5.	Apnea 03/01/2015 - "The 0.3 and 0.5 mg/kg doses of gantacurium abolished laryngospasm in 3 and 8 cats, respectively, and induced complete neuromuscular block measured at the pelvic limb; the mean ± SE duration of apnea was 2 ± 1 minutes and 3 ± 1.5 minutes, respectively. " 03/01/2015 - "Effect of gantacurium on evoked laryngospasm and duration of apnea in anesthetized healthy cats." 03/01/2015 - "To evaluate whether the ultrashort-acting neuromuscular blocking agent gantacurium can be used to blunt evoked laryngospasm in anesthetized cats and to determine the duration of apnea without hemoglobin desaturation. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
3.	Neuromuscular Blocking Agents
4.	Hemoglobins (Hemoglobin)
5.	AT 130