Dermatophagoides pteronyssinus antigen p 2

a 15 kD protein excreted in the feces by house dust mites Dermatophagoides pteronyssinus; has three intramolecular disulfide bonds; encoded by DERP2 gene; a group 2 Dermatophagoides allergen

Also Known As:

Networked: 96 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tsai, Jaw-Ji: 5 articles (01/2015 - 10/2005)
2.	Liao, En-Chih: 4 articles (01/2015 - 04/2013)
3.	Chen, Kuan-Wei: 3 articles (07/2015 - 05/2008)
4.	Vrtala, Susanne: 3 articles (07/2015 - 05/2008)
5.	Yu, Sheng-Jie: 3 articles (01/2015 - 10/2014)
6.	Chua, K Y: 3 articles (02/2009 - 03/2000)
7.	Chapman, Martin D: 2 articles (07/2022 - 10/2020)
8.	Glesner, Jill: 2 articles (07/2022 - 10/2020)
9.	Mueller, Geoffrey A: 2 articles (07/2022 - 10/2020)
10.	Peebles, R Stokes: 2 articles (07/2022 - 10/2020)

Related Diseases

1.	Asthma (Bronchial Asthma) 06/01/2014 - "An asthma mouse model in TLR4-deficient mice recently suggested that the allergic immune response against Der p 2 is solely dependent on TLR4 signaling. " 01/01/2013 - "These results improve our understanding of the cellular basis of Der p 2 BCG-mediated inhibition of asthma." 01/01/2013 - "Compared with BCG, Der p 2 rBCG displayed a more potent inhibitory effect on asthma responses, which may be related to the increase in plasmacytoid DC recruitment. " 01/01/2013 - "Der p 2 rBCG-DCs could effectively inhibit excessive Th2 immune responses and induced a subtype of CD4+CD25+Foxp3+ anti-specific regulatory T cells in this asthma model. " 08/01/2009 - "The human bronchial epithelial cell line BEAS-2B, normal human bronchial epithelial (NHBE) cells and the alveolar epithelial cell line A549 were exposed to recombinant Der p 2. Following exposure, we analysed a panel of soluble mediators and cell adhesion receptors involved in asthma pathogenesis by promoting recruitment, survival and binding of inflammatory cells. "
2.	Mite Infestations (Mange) 04/01/2013 - "Using the Der p 2 detection method to monitor environmental mite infestation may be beneficial for allergic subjects to prevent disease activation." 04/01/2013 - "The aims of this study were to monitor environmental mite infestation and to design an effective Der p 2 detection kit to estimate the number of mites in house dust samples. "
3.	Hypersensitivity (Allergy) 12/01/2022 - "Differences in mouse strains determine the outcome of Der p 2 allergy induction protocols." 09/01/2015 - "We examined whether single nucleotide polymorphisms (SNPs) in MD-2 promoter can affect MD-2 expression and aimed to clarify the relationship between Der p 2 allergy and SNPs of MD-2 promoter. " 05/01/2015 - "Association of Single Nucleotide Polymorphisms in the MD-2 Gene Promoter Region With Der p 2 Allergy." 03/01/2000 - "There were 82 asthmatic patients (41 adults and 41 children) with hypersensitivity to Dp who were analyzed for hypersensitivity to Der p 2. All of them were both skin test- and serology test-reactive to Dp. " 01/01/2022 - "This study also provides further evidence of the versatility of nanoallergens and their value for functional characterization of allergy epitopes, by ranking the Der p 2 epitopes according to immunogenicity. "
4.	Inflammation (Inflammations) 01/01/2013 - "The aim of this study was to determine whether DCs play a central role in the Der p 2 rBCG-mediated inhibition of allergic airway inflammation. " 09/01/2015 - "Enhanced Allergic Inflammation of Der p 2 Affected by Polymorphisms of MD-2 Promoter." 02/15/2015 - "As house dust mite (HDM) sensitization is dependent on TLR4 and HDM Der p 2, a structural homolog of MD-2, we also investigated the effect of MD-2s on HDM-induced allergic airway inflammation. " 12/01/2006 - "To investigate the efficacy and mechanism of subcutaneously given recombinant Der p 2 entrapped PLGA nanoparticles (DEPN) on mouse model with allergic airway inflammation. " 01/01/2013 - "Der p 2 recombinant bacille Calmette-Guérin targets dendritic cells to inhibit allergic airway inflammation in a mouse model of asthma."
5.	Rhinitis 04/05/2005 - "An estimated 79.2% patients with asthma, wheezing and/or rhinitis suffer from Dermatophagoides pteronyssinus group 2 (Der p 2) allegen. " 05/01/1992 - "SIs were compared between different clinical groups of patients, and patients with asthma had significantly higher values to both Der p I and Der p II than patients with rhinitis alone (17.0 +/- 5.4 versus 5.7 +/- 1.0 for Der p I, p less than 0.05; 14.3 +/- 6.8 versus 5.0 +/- 1.0 for Der p II, p less than 0.05)." 11/01/2003 - "The sensitization profile of rhinitis subjects to the dust mite allergens used in this study was as follows: Blo t extract positive: 91/124 (73%); Blo t 5 positive: 62/124 (50%); Der p extract positive: 61/124 (49%); Der p 1 positive: 53/124 (43%); Der p 2 positive: 45/124 (36%). " 01/01/1996 - "We used five purified major allergens (Der p 1, Der p 2, Fel d 1, Lol p 1, and Lol p 5) in skin tests, RASTs, and histamine release tests in 43 multisensitized patients with asthma or rhinitis. " 01/01/2015 - "Two-hundred immunotherapy-naïve patients with asthma and/or rhinitis positive to specific IgE (sIgE) against Der p extract, along with 20 Der p-negative nonallergic healthy controls, were tested for sIgE against Der p 1, Der p 2, and Der p 10 using ImmunoCAP 100. "

Related Drugs and Biologics

1.	Dermatophagoides pteronyssinus antigen p 1
2.	Immunoglobulin E (IgE)
3.	Allergens
4.	DNA (Deoxyribonucleic Acid)
5.	Vaccines
6.	DNA Vaccines
7.	Dermatophagoides farinae antigen f 2
8.	Immunoglobulin G (IgG)
9.	Pyridinolcarbamate (P23)
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics