Dermatophagoides farinae antigen f 2

A 15 kD protein excreted in the feces by house dust mites Dermatophagoides farinae; has three intramolecular disulfide bonds; encoded by DERF2 gene; a group 2 Dermatophagoides allergen

Also Known As:

Networked: 35 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lee, Jae Hyun: 2 articles (05/2019 - 09/2015)
2.	Park, Jung Won: 2 articles (05/2019 - 09/2015)
3.	Park, Kyung Hee: 2 articles (05/2019 - 09/2015)
4.	Han, Joong-Soo: 2 articles (01/2018 - 05/2013)
5.	Favrot, Claude: 1 article (04/2022)
6.	Iwasaki, Toshiro: 1 article (04/2022)
7.	Olivry, Thierry: 1 article (04/2022)
8.	Asero, R: 1 article (01/2022)
9.	Buzzulini, F: 1 article (01/2022)
10.	Conte, M: 1 article (01/2022)

Related Diseases

1.	Asthma (Bronchial Asthma) 12/01/2013 - "To determine the optimal condition of sensitization to recombinant Der f 2 (rDer f 2) in murine model of asthma, we compared the effectiveness with different adjuvants in BALB/c and C57BL/6 mice. " 12/01/2013 - "Influence of the Adjuvants and Genetic Background on the Asthma Model Using Recombinant Der f 2 in Mice." 05/01/2013 - "Interleukin-13 (IL-13), a gene associated with asthma pathology, was induced by Der f 2 in BEAS-2B human airway epithelial cells; however, the signaling pathways associated with Der f 2 are not fully understood. " 01/01/2012 - "farinae (Der f 2) and the Der f 2-specific IgE in sera of patients with asthma. " 01/01/2008 - "Chitosan microparticles loaded with mite group 2 allergen Der f 2 alleviate asthma in mice."
2.	Atopic Dermatitis (Atopic Eczema) 04/01/2021 - "farinae, Der f 2 and Zen 1 in dogs with atopic dermatitis and report if these dogs are in contact with material that could shelter mite allergens. " 12/01/2017 - "Dogs (n = 15) with atopic dermatitis were administered Der f 2 conjugated with pullulan (-P). " 12/01/2017 - "A pilot study of the effect of pullulan-conjugated Der f 2 allergen-specific immunotherapy on canine atopic dermatitis." 09/01/2015 - "This study aimed to investigate the sensitization profiles of Korean HDM allergic subjects suffering from respiratory allergy and atopic dermatitis (AD) to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20. " 10/15/2023 - "Currently, the major allergens related to D. farinae in dogs include Der f 2, Der f 15, Der f 18 and Zen 1. Canine atopic dermatitis remains a complex, genetically heterogeneous disease that is influenced by multiple environmental factors. "
3.	Hypersensitivity (Allergy) 05/01/2012 - "These results suggest that engineered hypoallergenic Der f 2 derivatives expressed in the rice seed endosperm could serve as a basis for the development of viable strategies for the oral delivery of vaccines against HDM allergy." 09/01/2015 - "This study aimed to investigate the sensitization profiles of Korean HDM allergic subjects suffering from respiratory allergy and atopic dermatitis (AD) to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20. " 09/01/1999 - "This article reports on the identification and SDS-PAGE continuous elution purification of a 16-kDa polypeptide that elicits immediate type hypersensitivity in calves and has sequence homology with known group II mite allergens, Lep d 2 of Lepidoglyphus destructor (Schrank), and Der f II of Dermatophagoides farinae (Hughes). " 03/01/1994 - "An immunoreactive clone, which shares no homology with the major allergens, Der f I and Der f II, was isolated by screening of a Dermatophagoides farinae cDNA library with rabbit antiserum raised against an extract of the house dust mite and sera from patients with mite allergy. " 09/01/2015 - "Specific IgE to Der f 2 alone was detected from 89.4% of HDM-sensitized respiratory allergy subjects and 92.3% to the combination of the 2 major allergens Der f 1 and Der f 2. However, sera from fewer patients with AD, namely 72.4% and 71.0%, recognized Der f 1 and Der f 2, respectively. "
4.	Dust Mite Allergy 08/01/1998 - "To establish a murine model for house dust mite allergy to purified mite allergens, we studied the immune response to two major mite allergens, native Dermatophagoides farinae 1 (nDer f 1) and recombinant Der f 2 (rDer f 2), and crude mite extract in four mouse strains, A/J, BALB/c, C57BL/6, and C3H/He. " 10/10/1997 - "Recombinant Der f 2 (rDer f 2) is a promising new allergen expected to improve the diagnosis and immunotherapy of house dust mite allergy and to further immunological studies. " 09/01/2015 - "Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients." 03/15/1999 - "To establish a guinea pig model for house dust mite allergy with purified mite allergens, we studied the immune response to two major mite allergens, native Der f 1 (nDer f 1) and recombinant Der f 2 (rDer f 2) and crude mite extract in Hartley guinea pigs. "
5.	Allergic Rhinitis 01/01/2023 - "The Der p 2 and Der f 2 IgE levels and positive rates were higher in the allergic rhinitis group. " 03/01/2009 - "To evaluate the effect of Dermatophagoides farinae fragments (Der f 2 N-peptides) that do not bind specific IgE in conjunction with the fungal immunomodulatory peptide fve (FIP-fve) on Treg cells derived from individuals with allergic rhinitis. " 01/01/2019 - "While SPT did not show any significant relationship between sensitization and type/severity of the respiratory disease, CRD allowed to associate Der p 1, Der f 1 and Lep d 2 sensitizations with asthma, and Der p 2, Der f 2 and Lep d 2 sensitizations with more severe symptoms of allergic rhinitis. "

Related Drugs and Biologics

1.	Allergens
2.	Dermatophagoides farinae antigen f 1
3.	Dermatophagoides pteronyssinus antigen p 2
4.	Dermatophagoides pteronyssinus antigen p 1
5.	Pyridinolcarbamate (P23)
6.	Cysteine Proteases (Cysteine Protease)
7.	Interleukin-13
8.	NF-kappa B (NF-kB)
9.	Phosphopyruvate Hydratase (Enolase)
10.	Indicators and Reagents (Reagents)

Related Therapies and Procedures

1.	Immunotherapy
2.	Oral Administration