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4-hydroxychalcone

structure in first source

Networked: 4 relevant articles (1 outcomes, 3 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Hackett, Peter T: 1 article (01/2022)
2.	Jia, Xuan: 1 article (01/2022)
3.	Li, Liangtao: 1 article (01/2022)
4.	Ward, Diane M: 1 article (01/2022)
5.	Aguilar-Medina, Elsa Maribel: 1 article (11/2019)
6.	Centurión, David: 1 article (11/2019)
7.	Montes-Avila, Julio: 1 article (11/2019)
8.	Osuna-Martínez, Ulises: 1 article (11/2019)
9.	Plazas-Guerrero, Carolina Gabriela: 1 article (11/2019)
10.	Ramos-Payán, Rosalío: 1 article (11/2019)

Related Diseases

1.	Disease Progression 01/01/2022 - "We show that top hits 4-hydroxychalcone and dibenzoylmethane increased mRNA levels of transcription factor nuclear factor erythroid 2-related factor 2 in FRDA patient-derived fibroblasts, as well as downstream antioxidant targets thioredoxin, glutathione reductase, and superoxide dismutase 2. Taken together, these findings reveal that FRDA progression may be in part due to oxidant-mediated decreases in Fxn and that some approved compounds may be effective in increasing mitochondrial Fxn in FRDA, delaying disease progression."
2.	Non-alcoholic Fatty Liver Disease 11/15/2019 - "However, it is imperative the existence of a specific treatment, due to this, the aim of this study was to determine the therapeutic effect of treatment with metformin, 4-hydroxychalcone or co-treatment on male Wistar rats with NAFLD. " 11/15/2019 - "Therapeutic effect of treatment with metformin and/or 4-hydroxychalcone in male Wistar rats with nonalcoholic fatty liver disease."
3.	Neuroblastoma 01/01/2019 - "4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells." 01/01/2019 - "In summary, this study identifies a cytotoxic effect of 4-hydroxychalcone in MYCN-amplified human neuroblastoma cells, which rationalizes its further study in the development of new therapies for pediatric neuroblastoma." 01/01/2019 - "Here, we report that 4-hydroxychalcone is a potent cytotoxin for MYCN-amplified IMR-32 and SK-N-BE (2) neuroblastoma cells, when compared to non-MYCN-amplified SH-SY5Y neuroblastoma cells and to the non-neuroblastoma human embryonic kidney cell line, HEK293t. "
4.	Hypertension (High Blood Pressure) 01/01/2014 - "In the present study, we aimed to investigate the preventive effects of 4-hydroxychalcone (4HCH) on resistant hypertension. "
5.	Neoplasms (Cancer) 01/01/2019 - "When combined with the anticancer drugs cisplatin or doxorubicin, 4-hydroxychalcone led to greater reductions in cell viability than was induced by either anti-cancer agent alone. "

Related Drugs and Biologics

1.	Oxidants (Oxidizing Agents)
2.	Transcription Factors (Transcription Factor)
3.	Messenger RNA (mRNA)
4.	Antioxidants
5.	thioredoxin glutathione reductase
6.	superoxide dismutase 2
7.	dibenzoylmethane
8.	Therapeutic Uses
9.	Metformin (Glucophage)
10.	Cryptochromes

Related Therapies and Procedures

1.	Therapeutics