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pentapeptide QYNAD

the endogenous pentapeptide QYNAD induces acute conduction block in the isolated rat sciatic nerve

Also Known As:

Gln-Tyr-Asn-Ala-Asp; glutaminyl-tyrosyl-asparaginyl-alanyl-aspartate

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - pentapeptide QYNAD: 5

Experts

1.	Görtz, P: 1 article (08/2005)
2.	Hartung, H P: 1 article (08/2005)
3.	Kieseier, B C: 1 article (08/2005)
4.	Otto, F: 1 article (08/2005)
5.	Siebler, M: 1 article (08/2005)
6.	Chakrabarti, K S: 1 article (03/2004)
7.	Mahalakshmi, R: 1 article (03/2004)
8.	Padmashri, R: 1 article (03/2004)
9.	Sahal, D: 1 article (03/2004)
10.	Sarma, S P: 1 article (03/2004)

Related Diseases

1.	Demyelinating Diseases (Demyelinating Disease) 12/04/2003 - "Reversible block of Na(+) channels by endogenous pentapeptide QYNAD has been reported to account for the fast relapses and remissions seen in autoimmune demyelinating disorders. " 01/28/2003 - "An endogenous pentapeptide (Gln-Tyr-Asn-Ala-Asp; QYNAD) that is present at elevated levels in human CSF from patients with demyelinating diseases has been reported to block voltage-gated sodium channels at low (10 micro M) concentrations. " 03/01/2004 - "The endogenous pentapeptide QYNAD (Gln-Tyr-Asn-Ala-Asp) is present in human cerebrospinal fluid (CSF), and its concentration is increased in demyelinating diseases. "
2.	Multiple Sclerosis 01/04/2002 - "The pentapeptide QYNAD, isolated from the cerebrospinal fluid from patients with multiple sclerosis (MS), blocked Na+ channels in various types of cultured cells. " 08/01/2005 - "Controversial data was published about the sodium channel-blocking effect of the endogenous pentapeptide QYNAD, which is elevated in patients with multiple sclerosis and Guillain-Barré-syndrome. "
3.	Guillain-Barre Syndrome 08/01/2005 - "Controversial data was published about the sodium channel-blocking effect of the endogenous pentapeptide QYNAD, which is elevated in patients with multiple sclerosis and Guillain-Barré-syndrome. "

Related Drugs and Biologics

1.	pentapeptide QYNAD
2.	Voltage-Gated Sodium Channels
3.	Sodium Channels (Sodium Channel)