WK175

decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells; no other info available 3/2002

Also Known As:

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yi-Ling: 1 article (07/2010)
2.	Huang, Tzu-Ting: 1 article (07/2010)
3.	Lai, Ming-Derg: 1 article (07/2010)
4.	Lin, Chi-Chen: 1 article (07/2010)
5.	Lin, Chiu-Mei: 1 article (07/2010)
6.	Weng, Tzu-Yang: 1 article (07/2010)
7.	Wu, Chao-Liang: 1 article (07/2010)
8.	Yang, Huei-Jiun: 1 article (07/2010)
9.	Yen, Meng-Chi: 1 article (07/2010)
10.	Hasmann, Max: 1 article (02/2002)

Related Diseases

1.	Leukemia 02/15/2002 - "WK175, a novel antitumor agent, decreases the intracellular nicotinamide adenine dinucleotide concentration and induces the apoptotic cascade in human leukemia cells." 02/15/2002 - "The apoptotic death signaling pathway initiated by WK175 was examined in detail: mitochondrial membrane potential, cytochrome c release, caspase 3 activation, caspase 3 and poly(ADP-ribose) polymerase cleavage, and the appearance of a sub-G(1) cell cycle population were determined in time course studies in THP-1 (a human monocytic leukemia cell line) cells. "
2.	Neoplasms (Cancer) 07/01/2010 - "The nicotinamide phosphoribosyl transferase (NAMPT) inhibitor APO866 (also called FK866 or WK175) selectively inhibits tumor growth through intracellular NAD depletion. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Cytochromes c (Cytochrome c)
3.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
4.	NAD (NADH)
5.	Transferases
6.	Niacinamide (Nicotinamide)
7.	Antineoplastic Agents (Antineoplastics)
8.	N- (4- (1- benzoylpiperidin- 4- yl)butyl)- 3- (pyridin- 3- yl)acrylamide