mu-calpain

07/01/2005 - "The present data indicate that mu-calpain proteolysis plays an important role in the chain of events following cerebral ischemia. "
01/01/1996 - "Further work is needed to characterize the extent, duration, and localization of mu-calpain activity during brain ischemia and reperfusion as well as its role in the causal pathway of postischemic neuronal injury."
01/01/1996 - "These results provide direct evidence for autolysis of brain mu-calpain during cerebral ischemia. "
01/01/1996 - "Brain mu-calpain autolysis during global cerebral ischemia."
09/01/2006 - "In this study, we investigated the effect of E64d, a mu-calpain and cathepsin B inhibitor, in the prevention of neuronal and endothelial apoptotic cell death after focal cerebral ischemia in rats. "

10/15/1998 - "Excessive mu-calpain activation has been linked to several cellular pathologies including excitotoxicity and ischemia. "
03/19/2010 - "Here, we studied the molecular interaction between activated mu-calpain and the lysosomal Hsp70.1 in the monkey hippocampal CA1 neurons after the ischemia-reperfusion insult. "
12/01/2007 - "The two fragments produced seem to be related to caspase-3 and mu-calpain activities, which are massively enhanced in tissues challenged by ischemia. "
02/16/2007 - "mu-Calpain was activated and p120-catenin was degraded after 36 h of ischemia in differentiated SH-SY5Y cells. "
09/26/2006 - "Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage."

09/01/2008 - "In the present study the influence of oxidation on activity and autolysis of mu-calpain was examined. "
10/15/2006 - "If the [Ca(2+)] is raised sufficiently for long enough to initiate substantial autolysis of mu-calpain, the Ca(2+) sensitivity of the proteolytic activity is greatly increased, and it remains active even at 300 nm Ca(2+), with activity only ceasing if the [Ca(2+)] is decreased to approximately 50 nm Ca(2+), close to the normal resting [Ca(2+)]. "
10/15/2006 - "[Ca(2+)] has to be raised to >/= 2 microm for >/= 1 min to initiate detectable autolysis of mu-calpain and to activate appreciable proteolytic activity. "
01/01/2006 - "No significant autolysis of mu-calpain or calpain-3 occurred as a result of the exercise. "
01/01/2006 - "Autolysis of calpain-3 was found to occur across a [Ca2+] range similar to that for mu-calpain, and both calpains displayed a seemingly higher Ca2+ sensitivity in human than in rat muscle homogenates, with approximately 15% autolysis observed after 1-min exposure to 2.5 microM Ca2+ in human muscle and almost none after 1- to 2-min exposure to the same [Ca2+]i level in rat muscle. "

02/01/1998 - "The detection of a shift in mu-calpain activity to the total membrane fraction first occurred at 3 hours after traumatic brain injury and became maximal at 24 hours after traumatic brain injury. "
10/01/1996 - "Our results indicate that rapid and persistent mu-calpain activation plays an important role in cortical neuronal degeneration after traumatic brain injury. "
10/01/1996 - "mu-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury."
02/01/1998 - "Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study."
01/01/2000 - "Casein zymogram assessment of mu-calpain and m-calpain activity after traumatic brain injury in the rat in vivo."

12/01/2004 - "Conversely, the active form of mu-calpain was not detected in normal cells, but was abundant after hypoxia. "
12/01/2004 - "The proform of mu-calpain was detected in the cytoplasm of normal cells, and displayed a substantial decrease after hypoxia. "
06/01/2004 - "The present study aimed to clarify the time-course of the activation of the mu-calpain, and the expression of c-Fos, c-Jun, HSP70 and HSP27 proteins following severe HI (2 h hypoxia) and their relationship with each other. "
12/01/2004 - "Mu-calpain is activated in human endometrial cells during hypoxia and that subsequent cleavage of the integrin beta3 cytoplasmic domain may give some adverse effects to the function of human endometrium."
12/01/2004 - "Western blot analysis confirmed that both the proform of mu-calpain and the integrin beta3 cytoplasmic domain decreased during hypoxia. "