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platinum 109

structure in first source

Also Known As:

pt109

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - platinum 109: 2

Experts

1.	Chen, Qiuhe: 2 articles (04/2022 - 09/2020)
2.	Lu, Junfeng: 2 articles (04/2022 - 09/2020)
3.	Pi, Rongbiao: 2 articles (04/2022 - 09/2020)
4.	Tu, Yalin: 2 articles (04/2022 - 09/2020)
5.	Wen, Shijun: 2 articles (04/2022 - 09/2020)
6.	Peng, Weijia: 1 article (04/2022)
7.	Yang, Yang: 1 article (04/2022)
8.	Yin, Wei: 1 article (04/2022)
9.	Zhang, Ji: 1 article (04/2022)
10.	Zhu, Wenbo: 1 article (04/2022)

Related Diseases

1.	Glioma (Gliomas) 04/05/2022 - "Metabolomics analysis showed that PT109 improved the aerobic respiration process in glioma cells. " 04/05/2022 - "Altogether, this work developed a novel anti-GBM small molecule PT109, which reprogramed GBM into oligodendrocytes and changed the metabolic pattern of GBM through the PTBP1/PKM1/2 pathway, providing a new strategy for the development of anti-glioma drugs."
2.	Pathologic Processes 09/15/2020 - "First, an 81-kinase screening was carried out and results showed that PT109 potently inhibited c-Jun N-terminal kinases and Serum and glucocorticoid-inducible kinase 1, which are the important signaling molecules involved in neurogenesis, neuroprotection and neuroinflammation and mildly inhibit glycogen synthase kinase-3β as well as protein kinase C gamma, both are involved in AD pathological processes. "
3.	Inflammation (Inflammations) 09/15/2020 - "Furthermore, the results of Western blot, ELISA assay and immunofluorescent staining indicated that PT109 attenuated lipopolysaccharide-induced inflammation in BV2 cells and primary astrocytes. "
4.	Glioblastoma (Glioblastoma Multiforme) 04/05/2022 - "PT109, a novel multi-kinase inhibitor suppresses glioblastoma multiforme through cell reprogramming: Involvement of PTBP1/PKM1/2 pathway."
5.	Alzheimer Disease (Alzheimer's Disease) 09/15/2020 - "Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo."

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