17- (dimethylaminoethylamino)- 17- demethoxygeldanamycin

structure in first source

Also Known As:

17-(dimethylaminoethylamino)-17-demethoxy-geldanamycin; 17-DMAG; 17-desmethoxy-17-n,n-dimethylaminoethylamino-geldanamycin; 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 17DMAG; KOS 1022; KOS-1022; KOS1022; NSC 707545; NSC707545; alvespimycin; ((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(2-dimethylaminoethylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo(16.3.1)docosa-4,6,10,18,21-pentaen-9-yl) carbamate

Networked: 143 relevant articles (18 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Qi, Jia: 5 articles (01/2021 - 01/2014)
2.	Akbarzadeh, Abolfazl: 4 articles (09/2018 - 01/2014)
3.	Mellatyar, Hassan: 4 articles (09/2018 - 01/2014)
4.	Lang, Sven A: 4 articles (09/2014 - 03/2007)
5.	Cheng, Pao-Yun: 3 articles (09/2019 - 01/2016)
6.	Lee, Yen-Mei: 3 articles (09/2019 - 01/2016)
7.	Talaei, Sona: 3 articles (09/2018 - 01/2016)
8.	Yang, Ping: 3 articles (04/2015 - 01/2014)
9.	Zhang, Jian: 3 articles (04/2015 - 01/2014)
10.	Kiang, Juliann G: 3 articles (09/2013 - 06/2011)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2009 - "Immunofluorescence staining confirmed the significant reduction in tumor HER-2 level upon 17-DMAG treatment. " 09/01/2009 - "Nude mice bearing SKOV-3 tumors were treated with 17-DMAG and the therapeutic efficacy was evaluated by tumor size measurement. " 12/01/2009 - "QC was also found to enhance the antitumor efficacy of proteotoxic stress inducers in vivo: combinatorial treatment with 17-DMAG + QC resulted in suppression of tumor growth in two mouse syngeneic models. " 01/01/2005 - "Peak plasma 17DMAG concentration was 15.4+/-1.4 microg/ml. The area under the plasma 17DMAG concentration versus time curve was 1072 microg/ml min, corresponding to a total body clearance of 70 ml/kg/min. Peak 17DMAG concentrations in liver (118.8+/-5.7 microg/g), kidney (122.9+/-10.6 microg/g), heart (81.3+/-8.1 microg/g), and lung (110.6+/-25.4 microg/g) occurred at 5-10 min, while peak concentrations in spleen (70.6+/-9.6 microg/g) and tumor (9.0+/-1.0 microg/g) occurred at 30-45 min. At 48 h, 17DMAG was detectable in tumor but not in any normal tissue. " 05/01/2013 - "The results suggest that combination of 17-DMAG and TNF treatments might be useful for treating malignancies upon further study in the further. "
2.	Infections 08/01/2013 - "Both oral and parenteral 17-DMAG cured mice of a normally lethal infection of T. " 08/01/2017 - "The Hsp90 inhibitor 17-DMAG decreases infection of porcine circovirus type 2 in mice." 11/01/2007 - "mellonella larvae pre-treated with 17-DMAG and exposed to mild heat-shock for 30min showed an increased survival rate after infection with entomopathogenic bacteria Pseudomonas aeruginosa. " 08/01/2017 - "These data demonstrate that 17-DMAG is highly effective in suppressing PCV2 replication in BALB/c mice, indicating that it has potential value as an antiviral drug against PCV2 infection." 11/20/2017 - "Indeed, it allows not only studying the infection and the dissemination of neurotropic viruses within the CNS but it could also serve as screening model of innovative antiviral strategies or molecules, such as our recently published studies about fusion inhibitory peptides and the HSP90 chaperone activity inhibitor, 17-DMAG ( Welsch et al., 2013 ; Bloyet et al., 2016 ). "
3.	Breast Neoplasms (Breast Cancer) 02/01/2018 - "Moreover, HSP90 inhibitors (17DMAG and HSP990) significantly decreased breast cancer stem-like CD24- CD44+ and side population (SP) cells in HCC1937 cells, but not in PRDM14 knockdown HCC1937 cells. " 01/01/2016 - "Targeting HSP90 Gene Expression with 17-DMAG Nanoparticles in Breast Cancer Cells." 02/15/2012 - "After in vitro 17-DMAG treatment response evaluation of MCF7 parental cells and 2 HER2-transfected clones (clone A medium, B high Her2 expression), we established human breast cancer xenografts in nude mice (only parental and clone B) for in vivo evaluation. " 10/01/2016 - "Our data indicate that 17-AEPGA and 17-DMAG are highly active in breast cancer cell lines and may help to overcome the delivery issues associated with the use of 17-AAG. " 10/01/2016 - "In vitro study comparing the efficacy of the water-soluble HSP90 inhibitors, 17-AEPGA and 17-DMAG, with that of the non‑water-soluble HSP90 inhibitor, 17-AAG, in breast cancer cell lines."
4.	Multiple Organ Failure (MODS) 01/01/2016 - "17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats." 01/01/2016 - "In this study, the beneficial effects of 17-DMAG on lipopolysaccharide (LPS) induced MODS and DIC was evaluated in anesthetized rats. " 01/01/2016 - "In conclusion, 17-DMAG possesses the anti-inflammatory and antioxidant effects that were proved through LPS-induced acute inflammation, which is associated with induction of HSP70 and HO-1, leading to prevent MODS in sepsis."
5.	Hematoma 10/01/2023 - "In this study, we found that treatment with 17-DMAG (5 mg/kg) effectively reduced hematoma expansion and resulted in improved neurological outcomes. " 10/01/2023 - "Additionally, silencing SOX5 blocked the protective effects of 17-DMAG on the BBB by inhibiting PI3K, p-Akt, and BBB TJPs levels, which led to an increase in EB and IgG leakage in the peri-hematoma tissue after ICH. " 10/01/2023 - "Furthermore, the injection of 17-DMAG decreased the infiltration of neutrophils into the brain tissues surrounding the hematoma in ICH rats and also reduced the production of proinflammatory cytokines IL-6 and TNF-α. "

Related Drugs and Biologics

1.	tanespimycin (17AAG)
2.	Proteins (Proteins, Gene)
3.	Antiviral Agents (Antivirals)
4.	Bleomycin (Blenoxane)
5.	Matrix Metalloproteinases (MMPs)
6.	Immunoglobulin G (IgG)
7.	Proteasome Inhibitors
8.	Glucose (Dextrose)
9.	Fluorescent Dyes (Fluorescent Probes)
10.	Endoplasmic Reticulum Chaperone BiP

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Ovariectomy (Oophorectomy)
4.	Ligation
5.	Lasers (Laser)