|1.||Gayo-Fung, Leah M: 3 articles (07/2003 - 03/2002)|
|2.||Anderson, David W: 3 articles (07/2003 - 03/2002)|
|3.||Stein, Bernd: 3 articles (07/2003 - 03/2002)|
|4.||Khammungkhune, Sak: 2 articles (03/2002 - 03/2002)|
|5.||Bhagwat, Shripad S: 2 articles (03/2002 - 03/2002)|
|6.||Brady, Helen: 2 articles (03/2002 - 03/2002)|
|7.||Sutherland, May Kung: 2 articles (03/2002 - 03/2002)|
|8.||Brady, Helen A: 1 article (07/2003)|
|9.||Lipps, Stephanie G: 1 article (07/2003)|
|10.||Xie, Weilin: 1 article (07/2003)|
|1.||Breast Neoplasms (Breast Cancer)
03/01/2002 - "The experiments described herein demonstrate that SP500263 is efficacious in the MCF-7 proliferation assay and in a murine model of breast cancer."
03/01/2002 - "Therefore, SP500263 is a member of a series of next-generation SERMs with functional selectivity toward ER-alpha and a mixed agonist/antagonist profile in a bone cell assay versus a breast cancer assay. "
03/01/2002 - "In contrast to the results observed in U2OS cells, SP500263 acts as a strong estrogen antagonist in an MCF-7 breast cancer proliferation assay. "
03/01/2002 - "Effects of SP500263, a novel, potent antiestrogen, on breast cancer cells and in xenograft models."
03/01/2002 - "We have compared the antitumor activities of SP500263, a novel next-generation selective estrogen receptor modulator (SERM), tamoxifen, and raloxifene side-by-side in in vitro and in vivo MCF-7 breast cancer models. "
|2.||Osteosarcoma (Osteogenic Sarcoma)
03/01/2002 - "To investigate the antitumor activity of SP500263 in animals, athymic nude mice were implanted with MCF-7 tumor in the presence of a tumor growth-supporting sustained release estrogen pellet. "
03/01/2002 - "dosing, effectively reduced estrogen-stimulated tumor growth at 3 and 30 mg/kg. SP500263 was as efficacious as tamoxifen and superior to raloxifene at the corresponding doses. "
|5.||Body Weight (Weight, Body)
|1.||Selective Estrogen Receptor Modulators (SERM)
|4.||Estrogen Receptor Modulators (Antiestrogen)
|5.||Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
|1.||Heterologous Transplantation (Xenotransplantation)