|1.||Lamy, Evelyn: 4 articles (12/2014 - 04/2009)|
|2.||Mersch-Sundermann, Volker: 4 articles (12/2014 - 04/2009)|
|3.||Herz, Corinna: 3 articles (12/2014 - 01/2013)|
|4.||Hertrampf, Anke: 3 articles (12/2014 - 01/2013)|
|5.||Erlacher, Miriam: 2 articles (12/2014 - 01/2013)|
|6.||Rohn, Sascha: 2 articles (12/2014 - 01/2013)|
|7.||Schüler, Julia: 2 articles (12/2014 - 01/2013)|
|8.||Wagner, Meike: 2 articles (12/2014 - 01/2013)|
|9.||Iori, Renato: 2 articles (09/2008 - 04/2004)|
|10.||Kleinhans, Claudia: 1 article (12/2014)|
01/01/2013 - "In conclusion, we could show here that the killing effect of MTBITC has a definite selectivity for cancer cells over normal liver cells and its cytotoxicity even applies for chemoresistant cancer initiating cells. "
01/01/2013 - "Growth arrest at G2/M and apoptosis induction was evident in all in vitro cancer models treated with MTBITC, including populations with cancer initiating characteristics. "
04/01/2004 - "To help elucidate whether the effects of MTBITC are specific for cancer cells, we tested MTBITC on freshly isolated, non-transformed human peripheral T lymphocytes. "
04/01/2004 - "Taking into account its in vitro antineoplastic activity and selectivity toward leukemia cells, MTBITC can be viewed as a conceptually promising agent in cancer therapy."
01/01/2013 - "Our data therefore imply that upon DNA damage by MTBITC, MAPK are essential for telomerase regulation and consequent growth impairment in liver tumor cells and this detail probably plays an important role in understanding the potential chemotherapeutic efficacy of ITC."
|2.||Hepatocellular Carcinoma (Hepatoma)
04/01/2009 - "In this study, we investigated the effect of 4-methylthiobutyl isothiocyante (MTBITC) on the proliferation of human hepatoma (HepG2) cells and underlying mechanisms. "
04/01/2009 - "This study shows for the first time the inhibitory potency of MTBITC on metabolically competent hepatoma cells, whereas the loss of reduced glutathione and its impact on mitochondria seem to be the major processes involved in the initiation and execution of the apoptotic cell death. "
12/01/2014 - "In animals and humans it was found to be quickly metabolized into 4-methylthiobutyl isothiocyanate (MTBITC, erucin) which we recently identified as strong selective apoptosis inducer in hepatocellular carcinoma (HCC) cells. "
|3.||Lung Neoplasms (Lung Cancer)
|4.||Liver Neoplasms (Liver Cancer)
01/01/2013 - "To clarify the role of MAPK for telomerase regulation, liver cancer cells were pre-treated with MAPK-specific inhibitors prior to MTBITC exposure. "
01/01/2013 - "Recently we demonstrated the potent growth inhibitory potential of the DNA damaging agent MTBITC in human liver cancer cells. "
12/01/2014 - "By using an orthotopic human liver cancer xenograft model, we give first evidence that MTBITC at 50 mg/KG b.w./d significantly decreased telomerase activity in vivo without affecting enzyme activity of adjacent normal tissue. "
|1.||Telomerase (Telomerase Reverse Transcriptase)
|2.||Glutathione (Reduced Glutathione)
|4.||Messenger RNA (mRNA)
|5.||DNA (Deoxyribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)