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bazedoxifene

Also Known As:
TSE 424; TSE-424; TSE424; WAY-140424; bazedoxifene acetate
Networked: 245 relevant articles (38 outcomes, 62 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Komm, Barry S: 25 articles (12/2017 - 09/2005)
2. Mirkin, Sebastian: 15 articles (11/2016 - 03/2010)
3. Lin, Jiayuh: 14 articles (05/2022 - 01/2016)
4. Chines, Arkadi A: 14 articles (08/2015 - 04/2008)
5. Pinkerton, JoAnn V: 13 articles (12/2021 - 11/2009)
6. Taylor, Hugh S: 10 articles (06/2018 - 05/2009)
7. Pickar, James H: 10 articles (05/2016 - 06/2005)
8. Li, Chenglong: 9 articles (02/2021 - 01/2016)
9. Archer, David F: 9 articles (11/2016 - 06/2005)
10. Constantine, Ginger D: 8 articles (07/2015 - 12/2008)

Related Diseases

1. Osteoporosis
2. Postmenopausal Osteoporosis
3. Neoplasms (Cancer)
4. Stroke (Strokes)
10/01/2016 - "Therefore, bazedoxifene could be useful in the treatment of cerebral disorders in which the cerebrovascular function is compromised (eg, stroke)."
12/01/2017 - "Bazedoxifene intervention results in no increase in adverse events (RR = 1.00; 95% CI = 0.99-1.00; P = .34), serious adverse events (RR = 1.04; 95% CI = 0.97-1.12; P = .31), myocardial infarction (RR = 0.88; 95% CI = 0.51-1.52; P = .64), stroke (RR = 0.97; 95% CI = 0.64-1.46; P = .87), venous thromboembolic event (RR = 1.56; 95% CI = 0.92-2.64; P = .10), and breast carcinoma (RR = 1.03; 95% CI = 0.59-1.79; P = .92). "
12/01/2017 - "Compared with placebo intervention for the osteoporosis of postmenopausal women, bazedoxifene intervention is found to significantly reduce the incidence of vertebral fracture and increase spine BMD at 3 and 7 years, and results in no increase in adverse events, serious adverse events, myocardial infarction, stroke, venous thromboembolic event, and breast carcinoma."
01/01/2019 - "Because neuroprotection in stroke should be revisited in the era of recanalisation, the present study analysed the potential neuroprotective effect of the selective oestrogen receptor modulator, bazedoxifene acetate (BZA), in an animal model of diabetic ischaemic stroke that mimics thrombectomy combined with adjuvant administration of a putative neuroprotectant. "
09/10/2011 - "Long-term studies of this combination are needed to determine if the combination of conjugated estrogens/bazedoxifene can be used for >3 years without increasing the risk of breast cancer, stroke, cognitive deficit, pulmonary embolism or coronary heart disease. "
5. Osteoporotic Fractures

Related Drugs and Biologics

1. Conjugated (USP) Estrogens (Premarin)
2. Selective Estrogen Receptor Modulators (SERM)
3. Raloxifene Hydrochloride (Evista)
4. Lasofoxifene
5. Diphosphonates (Bisphosphonates)
6. Estrogens (Estrogen)
7. Hormones (Hormone)
8. Ospemifene
9. Tamoxifen
10. Bromodeoxyuridine (BrdU)

Related Therapies and Procedures

1. Therapeutics
2. Hormone Replacement Therapy (Therapy, Hormone Replacement)
3. Thrombectomy
4. Oral Administration
5. Ovariectomy (Oophorectomy)