apiole

crystalline essential oil isolated directly from commercial oil of parsley

Also Known As:

1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene; 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole; apiol

Networked: 19 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Allylbenzene Derivatives: 4
        apiole: 19
  - Acyclic Hydrocarbons
    - Alkenes: 265
      - Allyl Compounds: 7
        Allylbenzene Derivatives: 4
        apiole: 19
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - apiole: 19

Experts

1.	Chang, Hui-Wen: 2 articles (07/2019 - 10/2012)
2.	Chen, Li-Ching: 2 articles (07/2019 - 10/2012)
3.	Ho, Yuan-Soon: 2 articles (07/2019 - 10/2012)
4.	Lien, Hsiu-Man: 2 articles (07/2019 - 10/2012)
5.	Afonso de Lima, Carolina: 1 article (10/2020)
6.	Barbarini Longato, Giovanna: 1 article (10/2020)
7.	Carvalho, João Ernesto de: 1 article (10/2020)
8.	Foglio, Mary Ann: 1 article (10/2020)
9.	Nunes Siqueira Vasconcelos, Stanley: 1 article (10/2020)
10.	Ruiz, Ana Lúcia Tasca Gois: 1 article (10/2020)

Related Diseases

1.	Neoplasms (Cancer) 07/27/2019 - "This study further explored the antitumor effects of apiole derivatives AP-02, 04, and 05 in COLO 205 cancer cells. " 07/27/2019 - "Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells." 10/01/2012 - "Our previous in vitro study demonstrated that apiole inhibits the growth of human colon (COLO 205) cancer cells through the arrest of the cell cycle in G0/G1 phase. " 07/27/2019 - "Human breast (MDA-MB-231, ZR75), lung (A549, PE089), colon (COLO 205, HT 29), and hepatocellular (Hep G2, Hep 3B) cancer cells were treated with apiole and its derivatives in a dose-dependent manner. " 10/01/2012 - "Our results show, for the first time, the promising antitumor effects of apiole against colon tumors in an in vivo xenograft model."
2.	Poisoning 10/01/1968 - "[Recent experience with poisoning with apiol and related compounds. " 10/01/1967 - "[Poisoning by apiole. " 07/01/1967 - "[Poisoning by apiole. " 04/01/1967 - "[Apiol poisoning. " 02/01/1964 - "[ON A CASE OF ACUTE AND FATAL POISONING CAUSED BY APIOL]."
3.	Colonic Neoplasms (Colon Cancer) 07/27/2019 - "Apiole was isolated from the leaves of various plants and vegetables and has been demonstrated to inhibit human colon cancer cell (COLO 205 cells) growth through induction of G0/G1 cell cycle arrest and apoptotic cell death. " 10/01/2012 - "Apiole (> 1×) markedly decreased the growth of COLO 205 human colon cancer cell tumor xenografts in an athymic nude mouse model system through the up-regulation of cell cycle regulators, such as p53, p21/Cip1, and p27/Kip1. "
4.	Carcinogenesis 12/01/2007 - "These results demonstrate that safrole, estragole, methyleugenol, myristicin, dill apiol, and parsley apiol are capable of altering the DNA in these cells and thus may contribute to human carcinogenesis."
5.	Acute Intermittent Porphyria (Porphyria, Acute) 01/01/1954 - "[Acute intermittent porphyria and apiol absorption]."

Related Drugs and Biologics

1.	myristicin
2.	Safrole (Safrol)
3.	antineoplaston A10 (A 10)
4.	apiole
5.	estragole (methyl chavicol)
6.	methyleugenol (methyl eugenol)
7.	elemicin
8.	Eugenol
9.	DNA (Deoxyribonucleic Acid)
10.	Anti-Infective Agents (Microbicides)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)