LY 393558

a 5-HT(1B,1D,2) receptor antagonist; structure in first source

Also Known As:

1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl)ethyl)-3-isopropyl-6-(methylsulfonyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine-2,2-dioxide; LY-393558; LY393558

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazines: 3
    - Thiadiazines: 4
      - LY 393558: 1
  - Cyclic S-Oxides
    - LY 393558: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - Thiadiazines: 4
      - LY 393558: 1
- Heterocyclic Oxides
  - Cyclic S-Oxides
    - LY 393558: 1

Experts

1.	Baranowska, Marta: 1 article (02/2010)
2.	Dempsie, Yvonne: 1 article (02/2010)
3.	Loughlin, Lynn: 1 article (02/2010)
4.	MacLean, Margaret R: 1 article (02/2010)
5.	Millet, Caroline: 1 article (02/2010)
6.	Morecroft, Ian: 1 article (02/2010)
7.	Nilsen, Margaret: 1 article (02/2010)
8.	Pang, Louisa: 1 article (02/2010)

Related Diseases

1.	Right Ventricular Hypertrophy 02/01/2010 - "We determined the effects of LY393558 as well as a selective serotonin transporter inhibitor, citalopram, on right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodelling in wildtype mice and mice over-expressing serotonin transporter (SERT+ mice) before and after hypoxic exposure. "
2.	Pulmonary Arterial Hypertension 02/01/2010 - "Here we determine, for the first time, the in vivo effects of a combined 5-HT1B receptor/serotonin transporter antagonist (LY393558) with respect to the development of pulmonary arterial hypertension (PAH) and its in vitro effects in human pulmonary artery smooth muscle cells (hPASMCs) derived from idiopathic PAH (IPAH) patients. "

Related Drugs and Biologics

1.	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)
2.	5-HT1B Serotonin Receptor
3.	Citalopram