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geoditin A

isolated from the sponge Geodia japonica collected from the South China Sea; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - geoditin A: 2
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Resorcinols: 4
        geoditin A: 2

Experts

1.	Che, Chun-Tao: 2 articles (02/2012 - 01/2010)
2.	Cheung, Florence W K: 2 articles (02/2012 - 01/2010)
3.	Liu, Wing-Keung: 2 articles (02/2012 - 01/2010)
4.	Guo, Jia: 1 article (02/2012)
5.	Ling, Yick-Hin: 1 article (02/2012)
6.	Li, Chunman: 1 article (01/2010)
7.	Liu, Bonnie P L: 1 article (01/2010)
8.	Wang, Lijun: 1 article (01/2010)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 01/19/2010 - "In this study, we found fragmentation of Golgi structure, suppression of transferrin receptor expression, production of oxidants, and DNA fragmentation in human colon cancer HT29 cells after treatment with geoditin A for 24 h. "
2.	Leukemia 02/01/2012 - "Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. " 01/19/2010 - "Geoditin A, an isomalabaricane triterpene isolated from the marine sponge Geodia japonica, has been demonstrated to dissipate mitochondrial membrane potential, activate caspase 3, decrease cytoplasmic proliferating cell nuclear antigen (PCNA), and induce apoptosis of leukemia cells, but the underlying mechanism remains unclear [1]. "
3.	Neoplasms (Cancer) 02/01/2012 - "Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. "
4.	Experimental Melanoma 02/01/2012 - "Anti-melanogenic property of geoditin A in murine B16 melanoma cells." 02/01/2012 - "Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell melanogenesis which was aggravated with adenylate cyclase inhibitor SQ22536, indicating melanogenic inhibition was mediated through a cAMP-dependent signaling pathway. "

Related Drugs and Biologics

1.	Oxidants (Oxidizing Agents)
2.	Transferrin Receptors (Transferrin Receptor)
3.	Triterpenes
4.	Caspase 3 (Caspase-3)
5.	Proliferating Cell Nuclear Antigen (PCNA)
6.	Proteins (Proteins, Gene)
7.	Adenylyl Cyclases (Adenylyl Cyclase)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)