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lipopeptidolactone

structure in first source

Also Known As:

RO-09-3655

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - lipopeptidolactone: 3
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - lipopeptidolactone: 3

Experts

1.	Horii, I: 2 articles (05/2001 - 02/2001)
2.	Inoue, T: 2 articles (05/2001 - 02/2001)
3.	Kobayashi, K: 2 articles (05/2001 - 02/2001)
4.	Kohchi, M: 2 articles (05/2001 - 02/2001)
5.	Kondoh, O: 2 articles (05/2001 - 02/2001)
6.	Masubuchi, K: 2 articles (05/2001 - 02/2001)
7.	Okada, T: 2 articles (05/2001 - 02/2001)
8.	Satoh, Y: 2 articles (05/2001 - 02/2001)
9.	Shimma, N: 2 articles (05/2001 - 02/2001)
10.	Yamazaki, T: 2 articles (05/2001 - 02/2001)

Related Diseases

1.	Systemic candidiasis 02/12/2001 - "Highly potent 1,3-beta-D-glucan synthase inhibitors 10, 11 and 13 have been identified by the chemical modification of the fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. D-Ornithine derivative (10) showed improved antifungal activity in the systemic candidiasis model in mice and reduced hepatotoxicity in vitro, as compared with 1." 05/21/2001 - "Highly potent 1,3-beta-D-glucan synthase inhibitors, 7b, 10a, 10b and 12, have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1."
2.	Pulmonary Aspergillosis 05/21/2001 - "Highly potent 1,3-beta-D-glucan synthase inhibitors, 7b, 10a, 10b and 12, have been identified by the chemical modification of the ornithine residue of a fungicidal macrocyclic lipopeptidolactone, RO-09-3655 (1), isolated from the cultured broth of Deuteromycotinia spp. These compounds showed stronger antifungal activity against systemic candidiasis as well as pulmonary aspergillosis in mice, and less hepatotoxicity as compared with 1."
3.	Mycoses (Diseases, Fungus) 07/18/2002 - "In our search for natural products with a broad spectrum of antifungal activity as lead compounds for novel treatments for mycoses, we have isolated echinocandin-type lipopeptide FR901379 and lipopeptidolactone FR901469, as novel water-soluble antifungal agents that inhibit the synthesis of 1,3-beta-glucan, a key component of the fungal cell wall. "

Related Drugs and Biologics

1.	lipopeptidolactone
2.	Ornithine
3.	Lipopeptides
4.	Echinocandins
5.	Antifungal Agents
6.	FR 901469
7.	FR 901379
8.	beta-1,3-glucan