|1.||Safe, Stephen: 7 articles (06/2015 - 01/2009)|
|2.||Lee, Syng-Ook: 4 articles (10/2014 - 03/2010)|
|3.||Sarkar, Fazlul H: 4 articles (07/2013 - 09/2008)|
|4.||Auborn, Karen J: 4 articles (01/2007 - 07/2003)|
|5.||Ahmad, Aamir: 3 articles (07/2013 - 09/2008)|
|6.||Kandala, Prabodh K: 3 articles (08/2012 - 01/2012)|
|7.||Srivastava, Sanjay K: 3 articles (08/2012 - 01/2012)|
|8.||Cho, Sung-Dae: 3 articles (09/2011 - 03/2010)|
|9.||Carter, Timothy H: 3 articles (03/2006 - 07/2003)|
|10.||Tjalkens, Ronald B: 2 articles (06/2015 - 10/2014)|
07/01/2003 - "This study examines the possibility that induction of growth arrest in response to DNA damage (GADD) in genes by diindolylmethane (DIM), which is the acid-catalyzed condensation product of I3C, promotes metabolically stressed cancer cells to undergo apoptosis. "
01/01/2015 - "Double-blind randomized placebo-controlled multicenter clinical trial (phase IIa) on diindolylmethane's efficacy and safety in the treatment of CIN: implications for cervical cancer prevention."
07/10/2013 - "Antioxidant function of isoflavone and 3,3'-diindolylmethane: are they important for cancer prevention and therapy?"
04/01/2013 - "Post-carcinogen administration of BRD, via intranasal instillation, for 24 weeks, twice a week, at a dose of 2mg per mouse (0.6mg pure diindolylmethane per mouse) reduced the lung tumor multiplicity to 4.6±2.2 tumors per mouse (72% reduction). "
01/01/2012 - "3,3'Diindolylmethane (DIM), a natural phytochemical, has shown inhibitory effects on the growth and migration of a variety of cancer cells; however, whether DIM has similar effects on vascular smooth muscle cells (VSMCs) remains unknown. "
|2.||Ovarian Neoplasms (Ovarian Cancer)
04/01/2012 - "In this study we show that diindolylmethane (DIM) induces autophagy in ovarian cancer cells by regulating endoplasmic reticulum (ER) stress and AMPK. "
08/17/2012 - "Treatment of various ovarian cancer cells by different concentrations of diindolylmethane (DIM), an active ingredient of cruciferous vegetables, reduced the anoikis resistance in a concentration-dependent manner. "
04/01/2012 - "We have reported previously that diindolylmethane (DIM) induces apoptosis in ovarian cancer cells by inhibiting STAT3. "
04/01/2012 - "Regulation of Janus-activated kinase-2 (JAK2) by diindolylmethane in ovarian cancer in vitro and in vivo."
01/01/2012 - "Diindolylmethane treatment induced apoptosis in all six ovarian cancer cell lines. "
|3.||Pancreatic Neoplasms (Pancreatic Cancer)
09/01/2008 - "Chemoprevention of pancreatic cancer: characterization of Par-4 and its modulation by 3,3' diindolylmethane (DIM)."
06/01/2011 - "Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors."
06/01/2011 - "Results of this and previous studies demonstrate that TR3 is unique among nuclear receptors since nuclear TR3 is activated or deactivated by diindolylmethane derivatives to induce different apoptotic and growth inhibitory pathways that inhibit pancreatic cancer cell and tumor growth."
08/15/2009 - "In the present study, we compared the expression of miRNAs between gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cells and investigated whether the treatment of cells with "natural agents" [3,3'-diindolylmethane (DIM) or isoflavone] could affect the expression of miRNAs. "
|4.||Prostatic Neoplasms (Prostate Cancer)
01/01/2010 - "A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer."
10/01/2012 - "The effect of the natural product diindolylmethane on cytosolic Ca(2+) concentrations ([Ca(2+)](i)) and viability in PC3 human prostate cancer cells was explored. "
10/01/2012 - "Effect of diindolylmethane on Ca2+ homeostasis and viability in PC3 human prostate cancer cells."
06/01/2014 - "Preclinical antitumor activity of the diindolylmethane formulation in xenograft mouse model of prostate cancer."
03/11/2008 - "[3,3-diindolylmethane enhances the inhibitory effect of idarubicin on the growth of human prostate cancer cells]."
|5.||Cervical Intraepithelial Neoplasia
04/01/2006 - "Indoles were used successfully in a very small clinical trial of women with high-grade cervical intraepithelial neoplasia and a larger trial using diindolylmethane in women with mildly abnormal cervical smears is underway. "
01/01/2015 - "The article presents the results of a clinical trial on the efficacy and safety of a novel pharmaceutical composition in the form of vaginal suppositories containing diindolylmethane in the course of cervical intraepithelial neoplasia (CIN) I-II conservative treatment. "
03/01/2010 - "Patients with biopsy-proven cervical intraepithelial neoplasia (CIN) 2 or 3 scheduled for loop electrosurgical excision procedure (LEEP) were randomized 2:1 to receive diindolylmethane (DIM) (BioResponse-DIM, BioResponse, Boulder, CO) orally at approximately 2 mg/kg/day for 12 weeks or placebo (defatted rice bran, BioResponse). "
|3.||Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
|4.||JNK Mitogen-Activated Protein Kinases
|6.||Transcription Factor AP-1 (Transcription Factor AP 1)
|1.||Heterologous Transplantation (Xenotransplantation)