HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

4-hydroxy-3-methylbut-2-enyl pyrophosphate

structure in first source
Also Known As:
HMB-PP
Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Eberl, Matthias: 6 articles (07/2013 - 04/2007)
2. Moser, Bernhard: 5 articles (07/2013 - 02/2009)
3. Topley, Nicholas: 3 articles (07/2013 - 02/2009)
4. Lin, Chan-Yu: 2 articles (07/2013 - 05/2011)
5. Vermijlen, David: 2 articles (05/2011 - 04/2007)
6. Roberts, Gareth W: 2 articles (05/2011 - 02/2009)
7. Williams, John D: 2 articles (05/2011 - 02/2009)
8. Kift-Morgan, Ann: 1 article (07/2013)
9. Mackay, Charles R: 1 article (01/2012)
10. Bansal, Raj R: 1 article (01/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
05/01/2011 - "The γδ T cell-driven perpetuation of inflammatory responses during acute peritonitis is associated with elevated peritoneal levels of γδ T cells and TNF-α and detrimental clinical outcomes in infections caused by HMB-PP positive microorganisms. "
01/01/2012 - "The interaction between HMB-PP-responsive Vγ9/Vδ2 T cells, IL-21-producing T(FH) cells and B cells in secondary lymphoid tissues is likely to impact on the generation of high affinity, class-switched antibodies in microbial infections."
05/01/2011 - "Human adult Vγ9Vδ2 T cells can be stimulated specifically via their TCR by phosphoantigens (as the pathogen-derived HMB-PP) or agents and infections that lead to their endogenous accumulation (as the aminobisphosphonate zoledronate). "
07/01/2013 - "We have previously shown that peritoneal dialysis (PD)-associated infections with HMB-PP producing bacteria are characterized by locally elevated γδ T-cell frequencies and poorer clinical outcome compared with HMB-PP negative infections, implying that γδ T cells may be of diagnostic, prognostic and therapeutic value in acute disease. "
12/01/2009 - "Our model incorporates the peculiar innate-like specificity of Vgamma9/Vdelta2 T cells for the microbial metabolite (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMB-PP), co-recruitment of monocytes and Vgamma9/Vdelta2 T cells to sites of infection, and their crosstalk, with profound consequences for the initiation of antigen-specific alphabeta T-cell responses. "
3. Peritonitis
4. Communicable Diseases (Infectious Diseases)
5. Acute Disease

Related Drugs and Biologics

1. Antigens
2. Carbon Monoxide
3. Antibodies
4. zoledronic acid (zoledronate)

Related Therapies and Procedures

1. Peritoneal Dialysis