difopein

11/30/2001 - "Because these kinases often become activated during oncogenesis, the effect of difopein on cell death induced by antineoplastic drugs was examined. "

04/01/2019 - "Suppressing overall 14-3-3 function by difopein overexpression or knocking-out the γ isoform of 14-3-3 is sufficient to abolish starvation-induced Beclin-1 induction and LC3 activation while overexpressing 14-3-3γ but no other 14-3-3 isoform significantly upregulate Beclin-1-LC3 signaling. "

02/01/2010 - "Difopein effectively hindered proliferation and triggered apoptosis of tumor cells implanted into nude mice. "
02/01/2010 - "Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice."

02/28/2019 - "These findings are consistent with 14-3-3ε acting as a proviral factor and suggest that 14-3-3ε siRNA and difopein are therapeutic candidates against PRRSV infection."

02/01/2010 - "In vivo, retroviral vector was constructed and retroviral-mediated transfer of difopein to glioma was implanted in nude mice. "
02/01/2010 - "In vitro, morphological observation and DNA laddering assay showed that difopein-treated glioma cells displayed outstanding apoptosis characteristics, such as nuclear fragmentation, appearance of membrane-enclosed apoptotic bodies and DNA laddering fragment. "
02/01/2010 - "Here, we further elucidated the role of 14-3-3 protein in apoptosis of human glioma U251 and U87 cells by global inhibition of 14-3-3 functions with a general 14-3-3 antagonist, difopein. "
02/01/2010 - "Targeting 14-3-3 protein, difopein induces apoptosis of human glioma cells and suppresses tumor growth in mice."
02/01/2010 - "Furthermore, RT-PCR and western blot assay further substantiated that difopein had strong effects to induce glioma cell apoptosis through down-regulating Bcl-2, up-regulating Bax and activating caspase-9 and caspase-3. "