aminoglycoside 2'-N-acetyltransferase

found in species of bacteria, acetylates and inactivates certain aminoglycosides and confers high-level resistance to these antibiotics when overexpressed

Also Known As:

AAC(2'); AAC(2')-Ia; AAC(2')-Ib; AAC(2')-Ic; aminoglycoside 2'-N-acetyltransferase Ia; aminoglycoside 2'-N-acetyltransferase Ib; aminoglycoside 2'-N-acetyltransferase Ic; gentamicin 2'-N-acetyltransferase

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        aminoglycoside 2'-N-acetyltransferase: 3

Experts

1.	Becker, Katja: 1 article (01/2018)
2.	Dal Molin, Michael: 1 article (01/2018)
3.	Gut, Myriam: 1 article (01/2018)
4.	Haldimann, Klara: 1 article (01/2018)
5.	Rominski, Anna: 1 article (01/2018)
6.	Sander, Peter: 1 article (01/2018)
7.	Giri, Ashok P: 1 article (01/2013)
8.	Jamdhade, Mahendra D: 1 article (01/2013)
9.	Joshi, Rakesh S: 1 article (01/2013)
10.	Sonawane, Mahesh S: 1 article (01/2013)

Related Diseases

1.	Acalculous Cholecystitis 07/01/2023 - "1. Percutaneous cholecystostomy (PC) is a safe and effective as a definitive treatment in patients with acute acalculous cholecystitis (AAC).2. PC can be safely removed after recover from AAC in the majority of patients (99.2%) with low rate of recurrence of cholecystitis (4.1%).3. Age-adjusted Charlson comorbidity index ≥7 was a risk factor for recurrence of cholecystitis after PC removal."
2.	Cholecystitis 07/01/2023 - "1. Percutaneous cholecystostomy (PC) is a safe and effective as a definitive treatment in patients with acute acalculous cholecystitis (AAC).2. PC can be safely removed after recover from AAC in the majority of patients (99.2%) with low rate of recurrence of cholecystitis (4.1%).3. Age-adjusted Charlson comorbidity index ≥7 was a risk factor for recurrence of cholecystitis after PC removal."
3.	Tuberculosis (Tuberculoses) 01/01/2018 - "Streptomycin, the first drug used for the treatment of tuberculosis, shows limited activity against the highly resistant pathogen Mycobacterium abscessus We recently identified two aminoglycoside-acetylating genes [aac(2') and eis2] which, however, do not affect susceptibility to streptomycin. " 01/01/2013 - "AA - amino acid, AT - Acetyltransferase, AAC - Aminoglycoside 2'-N-acetyltransferase, XDR - Extreme drug-resistant, MDR - Multidrug-resistant, Mtb - Mycobacterium tuberculosis, TB - Tuberculosis."

Related Drugs and Biologics

1.	Streptomycin (Streptomycin Sulfate)
2.	Aminoglycosides
3.	Amino Acids
4.	Acetyltransferases

Related Therapies and Procedures

1.	Cholecystostomy