ginsenoside Rb1

Also Known As:

3-GlcGlc-20-GlcGlc-ginsenoside; arasaponin E1; ginsenoside-Rb1; gynosaponin C; gypenoside III; notoginsenoside Rb1; panax saponin E; panaxoside Rb1; pseudoginsenoside D; sanchinoside E1; sanchinoside Rb1

Networked: 273 relevant articles (33 outcomes, 72 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Ginsenosides: 1010
        ginsenoside Rb1: 273
Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - Ginsenosides: 1010
      - ginsenoside Rb1: 273

Experts

1.	Yu, Zhen: 8 articles (01/2021 - 12/2011)
2.	Sun, Guibo: 6 articles (01/2022 - 01/2017)
3.	Sun, Xiaobo: 6 articles (01/2022 - 01/2017)
4.	Dong, Mei: 6 articles (01/2021 - 01/2017)
5.	Kim, Dong-Hyun: 6 articles (01/2013 - 04/2005)
6.	Li, Fang: 5 articles (03/2022 - 11/2015)
7.	Wang, Lei: 4 articles (12/2022 - 12/2014)
8.	Kim, Jong-Hoon: 4 articles (06/2022 - 04/2012)
9.	Kou, Junping: 4 articles (03/2022 - 12/2015)
10.	Yu, Boyang: 4 articles (03/2022 - 12/2015)

Related Diseases

1.	Inflammation (Inflammations) 09/01/2020 - "Ginsenoside Rb1 can effectively alleviate CAL in a mouse model of KD in a dose-dependent manner, possibly by regulating the AMPK/mTOR/P70S6 autophagy signaling pathway to inhibit CAL inflammation and regulating the PI3K/AKT/GSK-3β oxidative stress signaling pathway to exert a biological activity of protection against coronary artery endothelial cell injury." 01/01/2017 - "In conclusion, this study showed that ginsenoside Rb1 protects HUVECs from TNF-α-induced oxidative stress and inflammation by inhibiting JNK and p38. " 01/01/2017 - "This study showed that TNF-α-induced oxidative stress, inflammation and apoptosis in human umbilical vein endothelial cells (HUVECs) could be attenuated by ginsenoside Rb1 pretreatment. " 07/01/2016 - "Previous studies have demonstrated that ginsenoside Rb1 would prevent inflammation and apoptosis in chondrocytes. " 08/01/2023 - "Ginsenoside Rb1 (GsRb1) is one of the principal active components of ginseng, and has protective benefits against oxidative stress, inflammation, hypoxic injury, and so on. "
2.	Ischemia 01/01/2016 - "Recent studies have demonstrated that ginsenoside Rb1 protects the myocardium from ischemia-reperfusion (I/R) injury. " 09/01/2014 - "In this study, we examined the effect of Ginsenoside Rb1 (GRb1) on ischemia/reperfusion-induced autophagic neuronal death and investigated the role of PI3K/Akt. " 01/01/2017 - "Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway." 06/12/2012 - "Ginsenoside Rb1 attenuates intestinal ischemia reperfusion induced renal injury by activating Nrf2/ARE pathway." 03/26/2007 - "Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia."
3.	Myocardial Ischemia (Ischemic Heart Diseases) 10/01/2011 - "The objective of the current study is to investigate whether ginsenoside Rb1, a major pharmacological extract of ginseng that could attenuate myocardial ischemia reperfusion (MI/R) injury in non-diabetic myocardium, can attenuate MI/R injury in diabetes that are more vulnerable to ischemic insult. " 01/01/2011 - "The aim of this study was to investigate whether Ginsenoside Rb1 exerts cardioprotective effects during myocardial ischemia-reperfusion in diabetic rats and whether this effect is related to increase the production of NO via enhancing eNOS expression in the myocardium. " 12/01/2008 - "This is the first study to demonstrate that ginsenoside Rb1 preconditioning has protective effects on myocardial ischemia and reperfusion injury, partly by mediating the activation of the PI3K pathway and phosphorylation of Akt." 12/01/2008 - "This study investigated whether ginsenoside Rb1 preconditioning has protective effects on myocardial ischemia-reperfusion injury and its potential mechanism. " 03/01/2022 - "Ginsenoside Rb1 protects acute myocardial ischemia injury through promoting mitophagy via AMPKα phosphorylation, which might lay the foundation for the further application of Rb1 in cardiovascular diseases."
4.	Obesity 01/01/2014 - "Ginsenoside Rb1 is the main component of ginseng, however, there are only few studies examining its effects in obesity. " 12/01/2022 - "Ginsenoside Rb1 is the most abundant active component of Panax ginseng C.A.Mey (Araliaceae) and is reported to have beneficial effects on obesity and diabetes. " 01/01/2019 - "Hence, ginsenoside Rb1 may be developed as a potential anti-obesity, anti-hyperglycemic, and anti-diabetic agent with multi-target effects." 01/27/2021 - "Many studies have reported that ginsenoside Rb1 (G-Rb1) has activity against diabetes, inflammation, and obesity, but further investigation is needed on the effect and mechanism of G-Rb1 on browning. " 03/30/2023 - "Ginsenoside Rb1 Interfered with Macrophage Activation by Activating PPARγ to Inhibit Insulin Resistance in Obesity."
5.	Reperfusion Injury 01/01/2016 - "Analyzing the anti-ischemia-reperfusion injury effects of ginsenoside Rb1 mediated through the inhibition of p38α MAPK." 01/01/2011 - "It is concluded that Ginsenoside Rb1 protects against myocardium ischemia/reperfusion injury in diabetic rat by enhancing the expression of eNOS and increasing the content of NO as well as inhibiting oxidative stress." 01/01/2011 - "Ginsenoside Rb1 has been shown to confer cardioprotection against ischemia reperfusion injury. " 12/01/2008 - "This is the first study to demonstrate that ginsenoside Rb1 preconditioning has protective effects on myocardial ischemia and reperfusion injury, partly by mediating the activation of the PI3K pathway and phosphorylation of Akt." 12/01/2008 - "This study investigated whether ginsenoside Rb1 preconditioning has protective effects on myocardial ischemia-reperfusion injury and its potential mechanism. "

Related Drugs and Biologics

1.	Saponins
2.	Proteins (Proteins, Gene)
3.	Calcium
4.	Ginsenosides
5.	ginsenoside M1
6.	Glucose (Dextrose)
7.	Emodin (Archin)
8.	oxidized low density lipoprotein
9.	Chlorogenic Acid
10.	salvianolic acid B

Related Therapies and Procedures

1.	Oral Administration
2.	Intraventricular Infusions
3.	Therapeutics
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Drug Therapy (Chemotherapy)