physalin D

from Physalis alkekengi var. franchetti; structure in first source

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

1.	Liver Cirrhosis (Hepatic Cirrhosis) 11/01/2020 - "The present study investigated the protective effects of Physalin D (PD), a withanolide isolated from Physalis species (Solanaceae), against liver fibrosis and further elucidated the mechanisms involved in vitro and in vivo. " 11/01/2020 - "Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-β/Smad and YAP signaling."
2.	Acute Lung Injury 10/01/2021 - "leaves and physalin D inhibit P2X7 receptor function in vitro and acute lung injury in vivo."
3.	Pleurisy (Pleuritis) 10/01/2021 - "ATP and lipopolysaccharide (LPS)-induced pleurisy in mice were reversed for physalin D treatment. "
4.	Neoplasms (Cancer) 02/01/2006 - "In-vitro, both compounds displayed considerable cytotoxicity against several cancer cell lines, showing IC50 values in the range of 0.58 to 15.18 microg mL(-1) for physalin B, and 0.28 to 2.43 microg mL(-1) for physalin D. "
5.	Lymphoid Leukemia 05/01/1992 - "Physalin F also had an antitumor effect in vivo against P388 lymphocytic leukemia in mice whereas physalin D was inactive both in vitro and in vivo."