24-dihydroxy-5-cholestane 24-sulfate 3-N-1(spermine)-7

a spermine-cholesterol adduct which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice

Also Known As:

Networked: 17 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chiti, Fabrizio: 4 articles (01/2022 - 01/2018)
2.	Vendruscolo, Michele: 4 articles (01/2022 - 01/2018)
3.	Zasloff, Michael: 4 articles (01/2022 - 01/2018)
4.	Chen, Hsiao-Huei: 4 articles (01/2021 - 02/2015)
5.	Qin, Zhaohong: 4 articles (01/2021 - 02/2015)
6.	Stewart, Alexandre F R: 4 articles (01/2021 - 02/2015)
7.	Barbut, Denise: 3 articles (01/2022 - 01/2018)
8.	Knowles, Tuomas P J: 3 articles (01/2022 - 01/2018)
9.	Limbocker, Ryan: 3 articles (01/2022 - 01/2018)
10.	Zhang, Li: 3 articles (01/2021 - 10/2020)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 10/01/2020 - "Pharmacological inhibition of PTP1B with trodusquemine also restored trkB phosphorylation and improved schizophrenia-like behaviors by restoring eCB signaling, since the CB1 receptor antagonist 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide blocked this effect. " 01/01/2021 - "Our study suggests that the PTP1B inhibitor Trodusquemine may represent a new class of fast-acting antipsychotic drugs to treat schizophrenia-like symptoms."
2.	Body Weight (Weight, Body) 12/01/2022 - "Trodusquemine is an aminosterol with a variety of biological and pharmacological functions, such as acting as an antimicrobial, stimulating body weight loss and interfering with the toxicity of proteins involved in the development of Alzheimer's and Parkinson's diseases. " 08/01/2010 - "Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice. "
3.	Atherosclerotic Plaque (Atheroma) 10/01/2017 - "Acute (single dose) or chronic PTP1B inhibitor (trodusquemine) treatment of LDLR-/- mice decreased weight gain and adiposity, improved glucose homeostasis and attenuated atherosclerotic plaque formation. "
4.	Weight Gain 10/01/2017 - "Acute (single dose) or chronic PTP1B inhibitor (trodusquemine) treatment of LDLR-/- mice decreased weight gain and adiposity, improved glucose homeostasis and attenuated atherosclerotic plaque formation. "
5.	Obesity 08/01/2010 - "To better predict the potential effects of trodusquemine in the clinic, we investigated the effects of trodusquemine treatment in a murine model of diet-induced obesity (DIO). " 01/01/2021 - "Since Trodusquemine has undergone phase 1/2 clinical trials to treat obesity, it could be repurposed to treat Alzheimer's disease." 08/01/2010 - "Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity. " 06/01/2023 - "Initially discovered as a broad-spectrum antimicrobial agent, trodusquemine exhibited a variety of unexpected properties, ranging from antidiabetic and anti-obesity activities to effects useful to counteract cancer and neurodegeneration, which prompted its evaluation in several preclinical and clinical studies. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	CB1 Cannabinoid Receptor (CB1 Receptor)
3.	Leptin
4.	Insulin (Novolin)
5.	Hypoglycemic Agents (Hypoglycemics)
6.	Antipsychotic Agents (Antipsychotics)
7.	Anti-Infective Agents (Microbicides)
8.	Proteins (Proteins, Gene)
9.	squalamine
10.	Spermine

Related Therapies and Procedures

1.	Glycemic Control