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PD 0166285

structure in first source

Also Known As:

PD0166285

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - PD 0166285: 3

Experts

1.	Hashimoto, Osamu: 1 article (12/2006)
2.	Koga, Hironori: 1 article (12/2006)
3.	Nakamura, Toru: 1 article (12/2006)
4.	Sakamoto, Masaharu: 1 article (12/2006)
5.	Sata, Michio: 1 article (12/2006)
6.	Selvendiran, Karuppaiyah: 1 article (12/2006)
7.	Shinkawa, Masako: 1 article (12/2006)
8.	Torimura, Takuji: 1 article (12/2006)
9.	Ueno, Takato: 1 article (12/2006)
10.	Booher, R N: 1 article (11/2001)

Related Diseases

1.	Leukemia 10/07/2023 - "In this study, the WEE1 inhibitor PD0166285 showed a relatively good anti-leukemia effect. " 10/07/2023 - "HDAC11 mediates the ubiquitin-dependent degradation of p53 and inhibits the anti-leukemia effect of PD0166285."
2.	Neoplasms (Cancer) 10/07/2023 - "Moreover, HDAC11 can reduced the anti-tumor effect of PD0166285 through an effect on p53 stability and the changes in phosphorylation levels of MAPK pathways. " 12/19/2006 - "This G2 checkpoint abrogation by PD0166285 was demonstrated to kill cancer cells, there at a toxic highest dose of 0.5 muM in some cell lines for exposure periods of no longer than 6 hours. " 11/15/2001 - "At the cellular level, 0.5 microM PD0166285 dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines tested. "
3.	Experimental Melanoma 12/19/2006 - "We analyzed the effect of Wee1 inhibitor PD0166285 described first by Wang in the G2 transition in the B16 melanoma cell line. "
4.	Melanoma (Melanoma, Malignant) 12/19/2006 - "We herein report one of the mechanism by which PD0166285 leads to cell death in the B16 mouse melanoma cell line. " 12/19/2006 - "Cell cycle regulation by the Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line."

Related Drugs and Biologics

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