|1.||Handratta, Venkatesh D: 1 article (10/2004)|
|2.||Long, Brian J: 1 article (10/2004)|
|3.||Brodie, Angela M H: 1 article (10/2004)|
|4.||Kataria, Ritesh: 1 article (10/2004)|
|5.||Njar, Vincent C O: 1 article (10/2004)|
|6.||Jelovac, Danijela: 1 article (10/2004)|
|7.||Nnane, Ivo P: 1 article (10/2004)|
|8.||Njar, V C: 1 article (09/2001)|
|9.||Brodie, A A: 1 article (09/2001)|
|10.||Nnane, I P: 1 article (09/2001)|
|1.||Prostatic Neoplasms (Prostate Cancer)
10/01/1999 - "These results suggest that VN/85-1 and VN/87-1 may be potential candidates for treatment of prostate cancer."
10/01/2004 - "These results indicate that VN/85-1 or VN/87-1 may be useful in the treatment of hormone-dependent prostate cancer."
10/01/1999 - "We designed and evaluated two groups of azolyl steroids: delta5-non-competitive inhibitors (delta5NCIs), VN/63-1, VN/85-1, VN/87-1 and their corresponding delta4 derivatives (delta4NCIs), VN/107-1, VN/108-1 and VN/109-1. The human P450c17 gene was transfected into LNCaP human prostate cancer cells, and the resultant LNCaP-CYP17 cells were utilized to evaluate the inhibitory potency of the new azolyl steroids. "
10/01/2004 - "However, at their effective dosage regimes, VN/85-1 and VN/87-1 were each as effective as castration and more effective than finasteride or casodex, an anti-androgen used for prostate cancer (PC) therapy. "
09/01/2001 - "The pharmacokinetic parameters of VN/87-1 were not significantly altered in SCID mice bearing human LNCaP tumor xenografts. "
09/01/2001 - "The objective of this study was to assess the pharmacokinetics and bioavailability of 3beta-hydroxy-17-(1H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1) in normal male mice and in SCID mice bearing human LNCaP tumor xenografts. "
10/01/1999 - "In this model VN/85-1 was as effective as finasteride at inhibiting tumor growth (26% and 28% inhibition, respectively) and the inhibitory effect of VN/87-1 was similar to that of castration (33% and 36% inhibition respectively). "
|1.||3- hydroxy- 17- (imidazol- 1- yl)androsta- 5,16- diene
|3.||3- hydroxy- 17- (1H- 1,2,3- triazol- 1- yl)androsta- 5,16- diene
|1.||Heterologous Transplantation (Xenotransplantation)