|1.||Cuesta-Rubio, Osmany: 4 articles (04/2014 - 03/2002)|
|2.||Hilger, Ralf A: 3 articles (01/2013 - 03/2011)|
|3.||Holtrup, Frank: 3 articles (01/2013 - 03/2011)|
|4.||Bardenheuer, W: 3 articles (10/2010 - 08/2008)|
|5.||Díaz-Carballo, D: 3 articles (10/2010 - 08/2008)|
|6.||Malak, S: 3 articles (10/2010 - 08/2008)|
|7.||Nuñez-Figueredo, Yanier: 2 articles (04/2014 - 03/2011)|
|8.||Alberici, Luciane C: 2 articles (04/2014 - 03/2011)|
|9.||Curti, Carlos: 2 articles (04/2014 - 03/2011)|
|10.||Pardo-Andreu, Gilberto L: 2 articles (04/2014 - 03/2011)|
|1.||Breast Neoplasms (Breast Cancer)
01/15/2015 - "In comparison to breast cancer cells without treatment, nemorosone induced discrete cell cycle arrest in the G1 phase and significant depletion in the G2 phase. "
01/15/2015 - "Effects of nemorosone, isolated from the plant Clusia rosea, on the cell cycle and gene expression in MCF-7 BUS breast cancer cell lines."
01/01/2013 - "These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer."
01/01/2011 - "These findings suggest that nemorosone may have therapeutic application in the treatment of breast cancer because of its activity on ERα."
01/01/2011 - "Cytotoxic activity of nemorosone in human MCF-7 breast cancer cells."
01/01/2013 - "It is concluded that nemorosone is a potential anti-cancer lead compound with good bioavailability, little side-effects and promising growth-inhibitory effects, thus representing a valuable compound for a combination therapy approach. "
01/01/2013 - "Nemorosone has received increasing attention due to its strong in vitro anti-cancer action. "
03/01/2011 - "Therefore, nemorosone is a new potent protonophoric mitochondrial uncoupler and this property is potentially involved in its toxicity on cancer cells."
03/01/2011 - "Nemorosone, a natural-occurring polycyclic polyprenylated acylphloroglucinol, has received increasing attention due to its strong in vitro anti-cancer action. "
03/01/2011 - "The anti-cancer agent nemorosone is a new potent protonophoric mitochondrial uncoupler."
11/15/2012 - "The aim of this work was to characterize the antitumoral activity of the plant compound 7-epi-nemorosone in prostate carcinoma cell lines. "
11/15/2012 - "ERK1/2 protein levels and phosphorylation status were down-regulated accompanied by up-regulation but inhibition of the activity of their immediate upstream kinases MEK1/2. Additionally, Akt/PKB enzymatic activity was effectively inhibited at a similar concentration as for MEK1/2. Here, we demonstrate for the first time that 7-epi-nemorosone exerts cytotoxicity in an androgen-dependent prostate carcinoma entity by targeting the MEK1/2 signal transducer."
11/15/2012 - "7-epi-nemorosone from Clusia rosea induces apoptosis, androgen receptor down-regulation and dysregulation of PSA levels in LNCaP prostate carcinoma cells."
03/01/2002 - "We found that nemorosone has cytotoxic activity against epitheloid carcinoma (HeLa), epidermoid carcinoma (Hep-2), prostate cancer (PC-3) and central nervous system cancer (U251). "
10/01/2012 - "The separated enantiomers of this new PPAP, along with those of nemorosone and clusianone, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. "
|4.||Pancreatic Neoplasms (Pancreatic Cancer)
03/01/2011 - "Microarray analysis of nemorosone-induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR)."
01/01/2013 - "At a dose of 50 mg/kg nemorosone per day, a significant growth-inhibitory effect was observed in pancreatic cancer xenografts. "
01/01/2013 - "Thus, we investigated the growth-inhibitory potential of nemorosone on pancreatic cancer xenografts in NMRI nu/nu mice and determined basic pharmacokinetic parameters. "
01/01/2013 - "In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts."
03/01/2011 - "Nemorosone cytotoxicity was assessed by the resazurin proliferation assay on pancreatic cancer cells and fibroblasts. "
|4.||Cytochromes c (Cytochrome c)
|6.||Androgen Receptors (Androgen Receptor)
|9.||Adenosine Triphosphate (ATP)
|1.||Heterologous Transplantation (Xenotransplantation)