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phomoxanthone A

xanthone dimer from the endophytic fungus Phomopsis species; structure in first source

Also Known As:

phomo-xanthone A

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Xanthenes: 65
      - Xanthones: 211
        phomoxanthone A: 4

Experts

1.	Proksch, Peter: 3 articles (01/2020 - 12/2013)
2.	Stork, Björn: 2 articles (01/2020 - 12/2013)
3.	Wesselborg, Sebastian: 2 articles (01/2020 - 12/2013)
4.	Engelke, Laura: 2 articles (10/2019 - 12/2013)
5.	Hamacher, Alexandra: 2 articles (10/2019 - 12/2013)
6.	Kassack, Matthias U: 2 articles (10/2019 - 12/2013)
7.	Ceccacci, Sara: 1 article (01/2020)
8.	Deitersen, Jana: 1 article (01/2020)
9.	Monti, Maria Chiara: 1 article (01/2020)
10.	Morretta, Elva: 1 article (01/2020)

Related Diseases

1.	Neoplasms (Cancer) 12/15/2022 - "Phomoxanthone A is a naturally occurring molecule and a powerful anti-cancer agent, although its mechanism of action is unknown. " 10/01/2019 - "In the current study, we examined the anti-tumor activity of phomoxanthone A (PXA), a tetrahydroxanthone dimer isolated from the endophytic fungus Phomopsis longicolla, in several solid cancer cell lines and their cisplatin-resistant sub-cell lines. " 10/01/2019 - "The tetrahydroxanthone-dimer phomoxanthone A is a strong inducer of apoptosis in cisplatin-resistant solid cancer cells." 12/20/2013 - "Phomoxanthone A (1) showed the strongest pro-apoptotic activity when tested against a panel of human cancer cell lines, including cisplatin-resistant cells, whereas it was up to 100-fold less active against healthy blood cells. "
2.	Hyperammonemia 01/01/2020 - "Both approaches point to the identification of carbamoyl-phosphate synthase 1 as a major phomoxanthone A target in mitochondria cell lysates, giving also detailed insights into the ligand/target interaction sites by molecular docking and assessing an interesting phomoxanthone A stimulating activity on carbamoyl-phosphate synthase 1. Thus, phomoxanthone A can be regarded as an inspiring molecule for the development of new leads in counteracting hyperammonemia states."

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