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CDB 4022

a male contraceptive; structure in first source

Also Known As:

CDB-4022; CDB4022; RTI-4587-073

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        CDB 4022: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - CDB 4022: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - CDB 4022: 4

Experts

1.	Hild, Sheri Ann: 2 articles (07/2007 - 07/2004)
2.	Reel, Jerry R: 2 articles (07/2007 - 07/2004)
3.	Blye, R P: 2 articles (12/2001 - 07/2001)
4.	Hild, S A: 2 articles (12/2001 - 07/2001)
5.	Reel, J R: 2 articles (12/2001 - 07/2001)
6.	Dykstra, Michael J: 1 article (07/2007)
7.	Mann, Peter C: 1 article (07/2007)
8.	Marshall, Gary R: 1 article (07/2007)
9.	Attardi, Barbara J: 1 article (07/2004)
10.	Larner, J M: 1 article (12/2001)

Related Diseases

1.	Infertility (Sterility) 07/01/2004 - "CDB-4022 alone caused irreversible infertility in all males. " 12/01/2001 - "At the oral threshold dose (2.5 mg/kg), CDB-4022 induced infertility in all males. " 07/01/2001 - "Combined treatment also caused infertility in all six rats, but four of six recovered fertility (P = 0.08 compared to CDB-4022 alone). " 07/01/2001 - "CDB-4022 treatment resulted in infertility in all six rats, and only one of six regained fertility. " 07/01/2004 - "Suppression of ITT and possibly rFSH by acyline appeared to be crucial in preventing irreversible infertility induced by CDB-4022. "
2.	Necrosis 07/01/2007 - "CDB-4022 acts acutely on Sertoli cells to induce marked cellular rarefaction and degeneration, but not necrosis. "
3.	Body Weight (Weight, Body) 12/01/2001 - "CDB-4022 did not alter (P > 0.05) Leydig cell function as assessed by circulating testosterone, seminal vesicle, and ventral prostate weights or body weight gain compared to controls. "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Testosterone (Sustanon)
3.	Leuprolide (Lupron)
4.	acyline
5.	CDB 4022