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N6- (2- deoxy- erythro- pentofuranosyl)- 2,6- diamino- 4- hydroxy- 5- formamidopyrimidine

structure in first source

Also Known As:

Fapy-dG; N6-(2-deoxy-alpha,beta-D-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Formamides: 6
    - N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Formates: 7
      - Formamides: 6
        N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine: 2
  - Furans: 85
    - N6-(2-deoxy-erythro-pentofuranosyl)-2,6-diamino-4-hydroxy-5-formamidopyrimidine: 2

Experts

1.	Cammann, Sydney K: 1 article (01/2021)
2.	Lloyd, R Stephen: 1 article (01/2021)
3.	McCullough, Amanda K: 1 article (01/2021)
4.	Minko, Irina G: 1 article (01/2021)
5.	Moellmer, Samantha A: 1 article (01/2021)
6.	Owen, Nichole: 1 article (01/2021)
7.	Attaluri, Sivaprasad: 1 article (07/2011)
8.	Breslauer, Kenneth J: 1 article (07/2011)
9.	Johnson, Francis: 1 article (07/2011)
10.	Lukin, Mark: 1 article (07/2011)

Related Diseases

1.

Neoplasms (Cancer)

07/01/2011 - "Accumulation of damaged guanine nucleobases within genomic DNA, including the imidazole ring opened N(6)-(2-Deoxy-α,β-D-erythro-pentafuranosyl)-2,6-diamino-4-hydroxy-5-formylamidopyrimidine (Fapy-dG), is associated with progression of age-related diseases and cancer. "
01/01/2021 - "There is also evidence suggesting that inhibition of the BER enzyme 8-oxoguanine DNA glycosylase-1 (OGG1), which initiates repair of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (Fapy-dG), could be useful in treating certain cancers. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Guanine
3.	Enzymes
4.	8-Hydroxy-2'-Deoxyguanosine
5.	2,6- diamino- 4- hydroxy- 5- formamidopyrimidine
6.	imidazole
7.	8-hydroxyguanine