pentagalloylglucose

pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent

Also Known As:

1,2,3,4,6-PGG; 1,2,3,4,6-penta-O-galloyl beta-glucopyranose; 1,2,3,4,6-penta-O-galloyl-beta-D-glucose; 1,2,3,4,6-penta-O-galloyl-beta-glucose; 1,2,3,4,6-penta-O-galloylglucose; 1,2,3,4,6-pentagalloyl glucose; 1,2,3,4,6-pentagalloyl-D-glucose; 1,2,3,4,6-pentagalloylglucose; D-glucopyranose, pentakis(3,4,5-trihydroxybenzoate); beta-D-glucopyranose pentakis(3,4,5-trihydroxybenzoate); beta-D-glucopyranose, 1,2,3,4,6-pentakis(3,4,5-trihydroxybenzoate); beta-D-pentagalloylglucose; beta-penta-O-galloyl-glucose; beta-penta-O-galloyl-glucose, (D)-isomer; gallotannin 15; penta-1,2,3,4,6-O-galloyl-beta-D-glucose; penta-O-galloyl-D-glucose; penta-O-galloyl-alpha-D-glucopyranose; penta-O-galloyl-alpha-D-glucose; penta-O-galloyl-beta-D-glucoside

Networked: 29 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Sung-Hoon: 7 articles (01/2022 - 09/2008)
2.	Lü, Junxuan: 6 articles (08/2011 - 09/2008)
3.	Hu, Hongbo: 4 articles (08/2011 - 09/2008)
4.	Zhang, Jinhui: 4 articles (10/2010 - 09/2008)
5.	Lee, Hyo-Jung: 3 articles (01/2022 - 06/2011)
6.	Lee, Hyo-Jeong: 3 articles (08/2012 - 09/2008)
7.	Lin, Jen-Kun: 3 articles (08/2006 - 06/2003)
8.	Kim, Ji-Hyun: 2 articles (01/2022 - 08/2012)
9.	Jeong, Soo-Jin: 2 articles (08/2012 - 06/2011)
10.	Jung, Deok-Beom: 2 articles (08/2012 - 06/2011)

Related Diseases

1.	Acute Lung Injury 01/01/2019 - "Protective effects of ethyl gallate and pentagalloylglucose, the active components of Qingwen Baidu Decoction, against lipopolysaccharide-induced acute lung injury in rats."
2.	Neoplasms (Cancer) 09/21/2020 - "Also, the presence of Compound 1 (pentagalloylglucose) in the plant and its cancer cell-selective cytotoxicity provide some rationale for the ethno-medicinal use of the plant's leaf extract for treating diseases associated with excessive cell proliferation. " 09/21/2020 - "Pentagalloylglucose, isolated from the leaf extract of Anacardium occidentale L., could elicit rapid and selective cytotoxicity in cancer cells." 12/24/2013 - "The polyphenolic 1,2,3,4,6-penta-O-galloyl-beta-D-glucose from several medicinal herbs triggers apoptosis and has, thus, been proposed for treatment of malignancy. " 09/01/2008 - "Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo." 09/21/2020 - "Generation of reactive oxygen species at high concentrations of pentagalloylglucose to induce oxidative stress in cancer cells was identified as a mechanistic event that led to or resulted from its cytotoxicity. "
3.	Hepatocellular Carcinoma (Hepatoma) 12/10/2001 - "In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells." 08/01/2011 - "Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells." 12/10/2001 - "1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a major component of this crude drug, was found to exhibit in vitro growth-inhibiting effect on human hepatocellular carcinoma cell line, SK-HEP-1 cells. " 10/01/2010 - "The purpose of the study was a comparison of Oenothera paradoxa Hudziok defatted seeds extract (EPE) effect with the activity of individual constituents of the extract: pentagalloylglucose (PGG), gallic acid, (+)-catechin and the procyanidin fraction, as well as an assessment of the combined effect of EPE and vincristine (VCR) in the absence or presence of MRP1 (indomethacin) and P-glycoprotein (verapamil) inhibitors, on two human cancer cell lines, metastatic melanoma (HTB-140) and hepatoma (HepG2). "
4.	Radiation Injuries (Radiation Sickness) 08/01/2008 - "The study investigated the potential of Elaeocarpus sylvestris var. ellipticus (E.S.), which contains 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), to protect mice from radiation injury by single whole-body irradiation (WBI) in vivo. "
5.	Melanoma (Melanoma, Malignant) 10/01/2010 - "The purpose of the study was a comparison of Oenothera paradoxa Hudziok defatted seeds extract (EPE) effect with the activity of individual constituents of the extract: pentagalloylglucose (PGG), gallic acid, (+)-catechin and the procyanidin fraction, as well as an assessment of the combined effect of EPE and vincristine (VCR) in the absence or presence of MRP1 (indomethacin) and P-glycoprotein (verapamil) inhibitors, on two human cancer cell lines, metastatic melanoma (HTB-140) and hepatoma (HepG2). "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	qingwen baidu
3.	ethyl gallate
4.	Prostaglandins G
5.	Reactive Oxygen Species (Oxygen Radicals)
6.	Tannic Acid
7.	Member 1 Subfamily B ATP Binding Cassette Transporter
8.	Vincristine (Oncovin)
9.	Verapamil (Calan)
10.	Indomethacin (Indometacin)

Related Therapies and Procedures

1.	Chemoprevention
2.	Radiotherapy