1- ((1- O- octadecyl- 2- O- methylglycero)phospho)- 3- deoxy- myo- inositol

1.	Neoplasms (Cancer) 04/13/2001 - "OMDPI is currently being investigated as an anti-tumor agent by the National Cancer Institute, NIH" 10/01/2006 - "Phospho-Akt in mouse hair keratinocytes was inhibited by the Akt inhibitor PX-316 to a lesser degree than in MCF-7 tumor xenografts" 01/01/2004 - "Gene expression profiling of HT-29 tumor xenografts shows many similarities between the effects of PX-316 and the PtdIns-3-K inhibitor wortmannin, with downregulation of several ribosomal-related genes, while PX-316 uniquely increases the expression of a group of mitochondrial-related genes" 01/01/2004 - "PX-316 administered intraperitoneally to mice at 150 mg/kg inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h" 04/13/2001 - "An ether-containing phosphatidyl inositol(PI) analog, OMDPI, 1-[(1-O-octadecyl-2-O-methyl-sn-glycero)-phospho]-1D-3-deoxy-myo-inositol, is a potent inhibitor of this pathway and may be clinically useful in the treatment of a variety of neoplasms" Get all the results and reference details, order at left...
2.	Hemolysis 01/01/2004 - "PX-316 formulated in 20% hydroxypropyl-beta-cyclodextrin for intravenous administration is well tolerated in mice and rats with no hemolysis and no hematological toxicity" Get all the results and reference details, order at left...
3.	Colonic Neoplasms (Colon Cancer) 01/01/2004 - "PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice" Get all the results and reference details, order at left...
4.	Breast Neoplasms (Breast Cancer) 01/01/2004 - "PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice" Get all the results and reference details, order at left...
4 Diseases and 3 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	Phosphatidylinositols (Phosphatidylinositol)
2.	Inositol (Myoinositol)
3.	Ethyl Ether (Ether)
4.	Dihydrotachysterol (AT 10)
5.	2-hydroxypropyl-beta-cyclodextrin
6.	wortmannin
6 Drugs and Important Bio-Agents and 2 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
1 Therapies and Procedures and 2 more articles analyzed in the Research Interface, order at left...

Research Interface

Rapidly retrieve summaries of all the evidence for any disease in seconds. Save hours of search and analysis time. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time.

Unlimited Disease, Drug and Therapy Search
2 clicks from Disease to Drug to Evidence
Trial References
All the Positive Outcomes
Detailed Relationship Timeline Charts
Full Article Reference Details
Includes Mobile Interface Subscription
One-click to FDA Products/Patents
Request Institution License details >>

Price:

$490.00 access via web interface, 1 year subscription

Proceed to Checkout >>

Mobile Interface

Retrieve summaries of all the evidence for any disease from your Mobile Phone or PDA. Accelerate decision making in the field. Speed up your study of new drug and disease domains. Refresh your knowledge on the road.

Access from any web enabled PDA or Phone
Trial references
All the Positive Outcomes
Drug and Therapy searches
Full Article Reference Details
Try Mobile Interface >>

Price:

$45.00 access via "curehunter.com/m", 1 year subscription

Proceed to Checkout >>