galanin (2-11)-amide

Also Known As:
AR M1896; AR-M1896; ARM1896; GAL2-11; Gal(2-11)-NH2; Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-NH2; galanin (2-11)-NH2; tryptophyl-threonyl-leucyl-asparagyl-seryl-alanyl-glycyl-tyrosyl-leucyl-leucinamide
Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results


1. Wynick, David: 2 articles (01/2012 - 01/2011)
2. Donaldson, Lucy F: 2 articles (01/2012 - 01/2011)
3. Hulse, Richard P: 2 articles (01/2012 - 01/2011)
4. Yang, Xiangdong: 1 article (04/2012)
5. Liu, Zhen: 1 article (04/2012)
6. Xu, Xiaofeng: 1 article (04/2012)
7. Liu, Huaxiang: 1 article (04/2012)
8. Li, Zhenzhong: 1 article (04/2012)
9. Sperl, Wolfgang: 1 article (06/2003)
10. Humpel, Christian: 1 article (06/2003)

Related Diseases

1. Neuralgia (Stump Neuralgia)
08/14/2001 - "Here, we describe a generation of a specific galanin R2 (GalR2) agonist, AR-M1896, and its application in studies of a rat neuropathic pain model (Bennett). "
01/01/2011 - "In the present study we investigated the effects of direct administration into the receptive field of galanin and the galanin receptor-2/3-agonist Gal2-11 on nociceptive primary afferent mechanical responses in intact rats and mice and in the partial saphenous nerve injury (PSNI) model of neuropathic pain. "
04/05/2012 - "The effects of galanin, galanin receptor antagonist M35, galanin receptor 1 agonist M617, and galanin receptor 2 agonist AR-M1896 on neuropathic pain were evaluated by mechanical stimuli. "
01/01/2012 - "We then used the partial saphenous nerve ligation injury model of neuropathic pain (PSNI) and the complete Freund's adjuvant model of inflammation in the rat and demonstrated that close intra-arterial infusion of galanin, but not Gal2-11, reduced cooling evoked nociceptor activity and cooling allodynia in both paradigms, whilst galanin and Gal2-11 both decreased mechanical activation thresholds. "
04/05/2012 - "The results showed that (1) the diabetic rats showed a significant mechanical hyperalgesia between 4 and 12weeks; (2) galanin receptor 1 expression decreased in SDH in diabetic rats; (3) galanin receptor 2 expression decreased in DRG and SDH in diabetic rats; (4) intrathecal administration of exogenous galanin attenuated diabetic neuropathic pain, this effect could be blocked by pre-treatment with galanin receptor antagonist M35; and (5) intrathecal administration of galanin receptor 1 agonist M617, but not galanin receptor 2 agonist AR-M1896, attenuated diabetic neuropathic pain. "
2. Hyperalgesia
3. Neoplasms (Cancer)
4. Inflammation
5. Glioblastoma (Glioblastoma Multiforme)

Related Drugs and Biologics

1. Galanin
2. Type 2 Galanin Receptor
3. Type 1 Galanin Receptor
4. Galanin Receptors (Galanin Receptor)
5. Freund's Adjuvant

Related Therapies and Procedures

1. Ligation
2. Intra-Arterial Infusions