|1.||Guo, Shuhua: 2 articles (01/2005 - 11/2003)|
|2.||Gautrey, Hannah: 1 article (01/2013)|
|3.||Browell, David: 1 article (01/2013)|
|4.||Tyson-Capper, Alison: 1 article (01/2013)|
|5.||Jackson, Claire: 1 article (01/2013)|
|6.||Wan, Jing: 1 article (02/2009)|
|7.||Kole, Ryszard: 1 article (02/2009)|
|8.||Sazani, Peter: 1 article (02/2009)|
|9.||Feldmann, Marc: 1 article (10/2008)|
|10.||Paleolog, Ewa M: 1 article (10/2008)|
|1.||Glioblastoma (Glioblastoma Multiforme)
01/01/2005 - "Herstatin may have utility against glioblastoma driven by the EGFR but not the mutant DeltaEGFR. "
01/01/2005 - "Glioblastoma controlled by EGF receptor (EGFR; U87MG) or by the truncated mutant, DeltaEGFR (U87MG/Delta), were transfected with Herstatin and evaluated for in vitro and in vivo growth in nude rat brain. "
01/01/2005 - "Herstatin, an autoinhibitor of the epidermal growth factor receptor family, blocks the intracranial growth of glioblastoma."
01/01/2005 - "Herstatin, an autoinhibitor of the epidermal growth factor (EGF) receptor family, was evaluated for efficacy against human glioblastoma in vitro and in vivo in a rat intracranial model. "
01/01/2013 - "For example, the splice variant Δ16HER-2 (results from exon 16 skipping) increases transformation of cancer cells and is associated with treatment resistance; conversely, Herstatin (results from intron 8 retention) and p100 (results from intron 15 retention) inhibit tumour cell proliferation. "
07/01/2008 - "Herstatin (HST) is an alternatively spliced HER2 product with growth-inhibitory properties in experimental cancer systems. "
03/31/2006 - "A truncated ErbB2 extracellular domain, herstatin has been shown to bind to ErbB2 and inhibit the growth of tumor cells expressing ErbB2. "
01/01/2005 - "Herstatin expression prevented tumor formation by U87MG and purified Herstatin inhibited their growth in vitro in a dose-responsive fashion, whereas in vivo and in vitro growth of U87MG/Delta was resistant to Herstatin. "
07/01/2008 - "A splice variant of HER2 corresponding to Herstatin is expressed in the noncancerous breast and in breast carcinomas."
09/14/1999 - "The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. "
|4.||Breast Neoplasms (Breast Cancer)
02/15/2009 - "Delta15HER2 protein thus has similar activity to an autoinhibitory, natural splice variant of HER2, Herstatin, and to the breast cancer drug Herceptin. "
11/06/2003 - "Herstatin inhibits heregulin-mediated breast cancer cell growth and overcomes tamoxifen resistance in breast cancer cells that overexpress HER-2."
|1.||Epidermal Growth Factor Receptor (EGF Receptor)
|2.||Epidermal Growth Factor (EGF)
|3.||Neuregulin-1 (Neuregulin 1)
|5.||Messenger RNA (mRNA)