progenipoietin-1

a multifunctional agonist of the granulocyte colony-stimulating factor receptor and fetal liver tyrosine kinase-3; a potent mobilizer of hematopoietic stem cells

Also Known As:

Networked: 3 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hill, Geoffrey R: 2 articles (11/2005 - 03/2003)
2.	MacDonald, Kelli P A: 2 articles (11/2005 - 03/2003)
3.	Rowe, Vanessa: 2 articles (11/2005 - 03/2003)
4.	Banovic, Tatjana: 1 article (11/2005)
5.	Bofinger, Helen M: 1 article (11/2005)
6.	Burman, Angela C: 1 article (11/2005)
7.	Don, Alistair L J: 1 article (11/2005)
8.	Godfrey, Dale I: 1 article (11/2005)
9.	Kienzle, Norbert: 1 article (11/2005)
10.	Kuns, Rachel D: 1 article (11/2005)

Related Diseases

1.	Graft vs Host Disease (Graft-Versus-Host Disease) 03/01/2003 - "Donor pretreatment with progenipoietin-1 is superior to granulocyte colony-stimulating factor in preventing graft-versus-host disease after allogeneic stem cell transplantation." 11/01/2005 - "Following leukemic challenge, donor treatment with progenipoietin-1 significantly improved overall survival when compared with G-CSF or control, attributable to reduced graft-versus-host disease mortality and paradoxical augmentation of graft-versus-leukemia (GVL) effects. "
2.	Leukemia 11/01/2005 - "Following leukemic challenge, donor treatment with progenipoietin-1 significantly improved overall survival when compared with G-CSF or control, attributable to reduced graft-versus-host disease mortality and paradoxical augmentation of graft-versus-leukemia (GVL) effects. "
3.	Melanoma (Melanoma, Malignant) 04/01/2003 - "A phase I trial of SD-9427 (progenipoietin) with a multipeptide vaccine for resected metastatic melanoma." 04/01/2003 - "These data suggest that the majority of patients with resected melanoma mount an antigen-specific immune response against a multipeptide vaccine administered with SD-9427." 04/01/2003 - "The melanoma tumor antigen epitope peptides MART-1(26-35 (27L)), gp100(209-217 (210M)),and tyrosinase(368-376 (370D)) were emulsified with incomplete Freund's adjuvant and administered with SD-9427 (progenipoietin), an agonist of granulocyte colony-stimulating factor and the FLT-3 receptor, to evaluate the toxicities of and immune responses to this regimen as primary end points and time to relapse and survival as secondary end points. "
4.	Neutropenia 04/01/2003 - "One patient developed antibody-mediated leukopenia and transient grade III neutropenia that resolved after stopping SD-9427. " 04/01/2003 - "SD-9427 with a multipeptide vaccine was generally well tolerated, although one patient developed reversible antibody-mediated neutropenia. "
5.	Leukopenia 04/01/2003 - "One patient developed antibody-mediated leukopenia and transient grade III neutropenia that resolved after stopping SD-9427. "

Related Drugs and Biologics

1.	Granulocyte Colony-Stimulating Factor (G-CSF)
2.	Vaccines
3.	Peptides (Polypeptides)
4.	Neoplasm Antigens (Tumor Antigens)
5.	Antigens
6.	Epitopes
7.	incomplete Freund's adjuvant

Related Therapies and Procedures

1.	Stem Cell Transplantation