4- (3- (2- nitro- 1- imidazolyl)- propylamino)- 7- chloroquinoline hydrochloride

06/01/2011 - "Hypoxia-dependent retinal toxicity of NLCQ-1 (NSC 709257) in BALB/c mice. "
03/01/2007 - "DNA repair mechanisms are involved in the hypoxia-dependent toxicity of NLCQ-1 (NSC 709257) and its synergistic interaction with alkylating agents."
11/15/2003 - "NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug."
07/13/2010 - "The hypoxia-selective cytotoxin NLCQ-1 controls metastatic disease and may be a successful adjuvant to radiotherapy in the clinical setting."
07/13/2010 - "The hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) controls metastatic disease when used as an adjuvant to radiotherapy."

07/13/2010 - "Semi-quantitative grading of lung disease revealed a significant improvement with all treatments, with NLCQ-1 proving most efficacious (median grades: control, 4; NLCQ, 0 (P<0.0001); RB6145, 1 (P<0.001), tirapazamine, 3 (P=0.007)). "

05/01/2005 - "NLCQ-1 (NSC 709257) in combination with radiation against human glioma U251 xenografts."
05/01/2005 - "The above results suggest a significant advantage in combining radiation with NLCQ-1 against glioma tumors."
05/01/2005 - "The efficacy of the weak DNA-intercalative hypoxia-selective cytotoxin NLCQ-1 (NSC 709257) was investigated in combination with single or fractionated doses of radiation against human glioma U251 xenografts. "

07/01/2007 - "These results suggest a significant advantage in combining radiation with NLCQ-1 in treatment of human head and neck tumors, which are known to have hypoxic areas."
07/01/2007 - "Radiation given as a single dose of 10 Gy resulted in about 7 days of tumor growth delay, whereas in combination with NLCQ-1 about 30 additional days of delay were seen. "
07/01/2007 - "Radiation at 5 Gy given in two doses 10 days apart resulted in 3.5 days of tumor growth delay, whereas more than 20 additional days of delay were observed in combination with NLCQ-1. "
07/01/2007 - "Radiation at 1 Gy given once daily for 4 days on days 20 and 30 caused 3.5 days of tumor growth delay, whereas in combination with NLCQ-1 it caused 14.5 days of growth delay. "
07/01/2007 - "NLCQ-1 alone resulted in about 10 days of tumor growth delay, measured at sixfold the tumor's original size, without causing toxicity. "

05/01/2005 - "When NLCQ-1 was added to the above protocol an optimal TIC value of -100 and 9 out of 10 complete regressions were obtained with a follow-up of 52 days. "