|1.||Okuda-Ashitaka, Emiko: 3 articles (02/2006 - 10/2002)|
|2.||Ito, Seiji: 3 articles (02/2006 - 10/2002)|
|3.||Minami, Toshiaki: 3 articles (02/2006 - 10/2002)|
|4.||Matsumura, Shinji: 2 articles (02/2006 - 04/2003)|
|5.||Zhang, Y: 1 article (01/2015)|
|6.||Standifer, K M: 1 article (01/2015)|
|7.||Simpson-Durand, C D: 1 article (01/2015)|
|8.||Kabashima, Kenji: 1 article (01/2014)|
|9.||Narumiya, Shuh: 1 article (01/2014)|
|10.||Watanabe, Takeshi: 1 article (01/2014)|
01/01/2015 - "JTC-801 treatment reversed SPS-induced mechanical allodynia, thermal hyperalgesia, anxiety-like behaviour and hypocortisolism. "
02/01/2006 - "JTC-801 dose-dependently blocked the N/OFQ- and PGE(2)-induced allodynia, but not the PGF(2alpha)-induced one. "
10/01/2002 - "JTC-801 did not induce allodynia by itself. "
10/01/2002 - "Allodynia and hyperalgesia evoked by intrathecal administration of Noc/OFQ (50 pg/mouse) were dose dependently blocked by simultaneous administration of JTC-801 with IC(50) values of 32.2 and 363 pg, respectively. "
04/01/2003 - "Oral administration of JTC-801 relieved the thermal hyperalgesia in neuropathic mice in a dose-dependent manner. "
|2.||Neuralgia (Stump Neuralgia)
04/01/2003 - "In the present study, we studied the effect of JTC-801 on neuropathic pain induced by L5 spinal nerve transection in mice. "
04/01/2003 - "These results suggest that N/OFQ is involved in the maintenance of neuropathic pain and that the analgesic effect of JTC-801 on neuropathic pain is mediated by inhibition of NO production by neuronal NOS."
11/20/2003 - "JTC-801, given orally in food, alleviated heat-evoked hyperalgesia in CCI rats, suggesting that it is useful for the treatment of neuropathic pain."
11/20/2003 - "Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model."
03/14/2005 - "In conclusion, N/OFQ receptor antagonist JTC-801 exerted anti-allodynic and anti-hyperalgesic effects in rats, suggesting that N/OFQ system might be involved in the modulation of neuropathic pain and inflammatory hyperalgesia."
01/01/2015 - "JTC-801 reversed SPS-induced anxiety- and pain-like behaviours, and NOP receptor system up-regulation. "
10/01/2002 - "Furthermore, both phases of 2% formalin-induced pain behaviors were relieved by JTC-801. "
01/01/2015 - "Here, we determined the effect of JTC-801 (N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride), a nociceptin/orphanin FQ peptide (NOP) receptor antagonist, on symptoms of pain and anxiety in rats after SPS exposure, and examined N/OFQ-NOP receptor system changes. "
10/01/2002 - "These results demonstrate that pronociceptive responses induced by a low dose of Noc/OFQ may be mediated through the Noc/OFQ receptor in the spinal cord and that JTC-801 can be a useful antagonist to examine the involvement of endogenous Noc/OFQ and mediation of the Noc/OFQ receptor under physiological and pathophysiological conditions including pain."
01/01/2002 - "We have demonstrated that JTC-801 antagonizes the ORL(1) receptor response, and that JTC-801 has efficacious and potent anti-nociceptive effects in acute pain animal models not only by intravenous injection but also oral administration. "
01/01/2014 - "In addition, oral administration of JTC801 promoted the protein level of Flg and suppressed the development of AD-like skin inflammation in NC/Nga mice. "
03/14/2005 - "Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation."
|5.||Post-Traumatic Stress Disorders (PTSD)
|3.||Win 55212-2 (WIN 55,212)
|4.||CB1 Cannabinoid Receptor (CB1 Receptor)
|6.||Peptide Receptors (Peptide Receptor)
|7.||Nitric Oxide (Nitrogen Monoxide)