1- (2,4- dichlorobenzyl)indazole- 3- carbohydrazide (adjudin)

12/01/2018 - "Adjudin treatment significantly attenuated cerebral edema on Day 3 and improved neurobehavioral outcomes on Days 3, 7, and 14 after CCI injury, compared with the vehicle group. "
12/01/2018 - "These findings suggest that adjudin is a potential therapeutic intervention preventing the development of cerebral edema after TBI."
12/01/2018 - "In conclusion, adjudin attenuated the development of TBI-induced cerebral edema at least partly via anti-inflammatory effects and inhibition of the NF-κB pathway. "
12/01/2018 - "Hence, we investigated the effects of adjudin on cerebral edema using a mouse model of TBI and explored the underlying mechanisms. "
12/01/2018 - "Adjudin Attenuates Cerebral Edema and Improves Neurological Function in Mice with Experimental Traumatic Brain Injury."

11/01/2006 - "These data confirm that Adjudin is effective in reducing the strength of the STJC, identifying Adjudin as a potential contraceptive agent in the male by inducing spermatid sloughing and therefore oligospermia."

04/01/2011 - "Earlier studies have shown adjudin to cause aspermatogenesis by depleting virtually all germ cells from the seminiferous epithelium, leading to transient infertility; spermatogenesis and fertility were re-established several weeks later after germ cell proliferation and differentiation were reinitiated by spermatogonia. "
02/01/2012 - "Spermatogonial stem cells alone are not sufficient to re-initiate spermatogenesis in the rat testis following adjudin-induced infertility."
10/01/2011 - "Since the population of spermatogonia and spermatogonial stem cells (SSCs) in the seminiferous tubules is not significantly reduced by the treatment of rats with adjudin, adjudin-induced infertility is highly reversible, which enables reinitiation of spermatogenesis and germ cell re-population of the voided seminiferous epithelium. "
10/01/2009 - "Adjudin is known to specifically affect Sertoli-germ cell adhesion, resulting in germ cell loss from the seminiferous epithelium and transient infertility. "
01/01/2009 - "Manipulation of these interactions by drugs like Adjudin can hamper the development of germ cells and lead to conditions of temporary infertility. "

02/01/2013 - "Intraperitoneal administration of Adjudin to tumor-bearing athymic nude mice also significantly suppressed the lung and prostate tumor growth. "
02/01/2013 - "We found that Adjudin induced apoptosis in cancer cells through a Caspase-3-dependent pathway. "
02/01/2013 - "Herein we described the anti-proliferative activity of Adjudin on cancer cells in vitro and on lung and prostate tumors inoculated in nude mice. "
02/01/2013 - "However, whether Adjudin exhibits any anti-cancer activity remains to be elucidated. "
02/01/2013 - "Taken together, these findings have demonstrated that Adjudin may be a potential drug for cancer therapy."

01/15/2013 - "Thus, our data suggest that Adjudin may be useful for mitigating neuroinflammation."
06/14/2014 - "Together these data demonstrate that adjudin protects against cerebral ischemia reperfusion injury, and we present an effective neuroinflammation modulator with clinical potential. "
06/14/2014 - "Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption."
01/01/2022 - "Adjudin prevents neuronal damage and neuroinflammation via inhibiting mTOR activation against pilocarpine-induced status epilepticus."
12/01/2018 - "Further, adjudin treatment significantly decreased the gene and protein expression of aquaporin 4 in post-injury mice and inhibited progression of neuroinflammation in both mice and cultured astrocytes. "