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germacranolide

from Artemisia pallens; structure in first source

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Monocyclic Sesquiterpenes: 14
        Germacrane Sesquiterpenes: 1
        germacranolide: 8

Experts

1.	Babu, Gajendran: 1 article (07/2021)
2.	Krishnapriya, Madhu Varier: 1 article (07/2021)
3.	Li, Yan-Mei: 1 article (07/2021)
4.	Long, Qun: 1 article (07/2021)
5.	Qiu, Jian-Fei: 1 article (07/2021)
6.	Rao, Qing: 1 article (07/2021)
7.	Song, Jing-Rui: 1 article (07/2021)
8.	Sun, Mao: 1 article (07/2021)
9.	Yan, Chen: 1 article (07/2021)
10.	Yi, Ping: 1 article (07/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 11/27/2023 - "A highly oxidized germacranolide from elephantopus tomentosus inhibits the growth of hepatocellular carcinoma cells by targeting EGFR in vitro and in vivo." 01/01/2023 - "Design and synthesis of guaianolide-germacranolide heterodimers as novel anticancer agents against hepatocellular carcinoma." 11/01/2020 - "All germacranolide sesquiterpenes were screened to determine their inhibitory effects with two hepatoma cell lines (HepG2 and Hep3B), and compounds 14, 16, 18, 19 and 20 showed significant cytotoxic activities against the HepG2 (IC50, 3.3-9.9 μM) and Hep3B (IC50, 4.5-8.6 μM) cell lines. "
2.	Leukemia 07/01/2021 - "Germacranolide sesquiterpenes from Carpesium cernuum and their anti-leukemia activity." 10/15/2002 - "Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone."
3.	Carcinogenesis 10/15/2002 - "Costunolide, a germacranolide sesquiterpene lactone that exists in several medicinal plants, is known to be a possible anti-cancer and chemopreventive agent for tumorigenesis. "
4.	Neoplasms (Cancer) 10/15/2002 - "Costunolide, a germacranolide sesquiterpene lactone that exists in several medicinal plants, is known to be a possible anti-cancer and chemopreventive agent for tumorigenesis. "
5.	Melanoma (Melanoma, Malignant) 01/27/2023 - "Hirsutinolide derivatives 7a (CC50 = 5.0 µM; SI = 2.5) and 7b (CC50 = 11.2 µM; SI = 2.5) and the germacranolide derivative 8a (CC50 = 3.1 µM; SI = 3.0) revealed significant cytotoxic activity and selectivity against human melanoma SK-MEL-28 cells when compared with that against non-tumoral HUVEC cells. "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	Lactones
3.	Hydralazine (Apresoline)
4.	Cisplatin (Platino)
5.	Antineoplastic Agents (Antineoplastics)
6.	sintenin
7.	costunolide