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7(2- (5- hydroxybenzo(b)thiophen- 3- ylcarbonylamino)- 10- norpinan- 3- yl)hept- 5- enoic acid

Also Known As:

((Z)-7-(1R,2R,3S,5S)-2-(5-hydroxybenzo(b)thiophen-3-ylcarbonylamino)-10-norpinan-3-yl)hept-5-enoic acid; S 5751; S-5751; S5751

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 7(2-(5-hydroxybenzo(b)thiophen-3-ylcarbonylamino)-10-norpinan-3-yl)hept-5-enoic acid: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 7(2-(5-hydroxybenzo(b)thiophen-3-ylcarbonylamino)-10-norpinan-3-yl)hept-5-enoic acid: 4

Experts

1.	Arimura, Akinori: 2 articles (09/2011 - 01/2008)
2.	Asanuma, Fujio: 2 articles (09/2011 - 01/2008)
3.	Hirano, Yosuke: 2 articles (09/2011 - 01/2008)
4.	Shichijo, Michitaka: 2 articles (09/2011 - 01/2008)
5.	Yasui, Kiyoshi: 2 articles (09/2011 - 01/2008)
6.	Arimura, A: 2 articles (09/2009 - 08/2001)
7.	Yasui, K: 2 articles (09/2009 - 08/2001)
8.	Furue, Yoko: 1 article (09/2011)
9.	Ikeda, Minoru: 1 article (09/2011)
10.	Imura, Kinichi: 1 article (09/2011)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2001 - "Here, we report the in vivo efficacy of our newly established DP receptor antagonist, S-5751 [((Z)-7-[(1R,2R,3S,5S)-2-(5-hydroxy benzo[b]thiophen-3-ylcarbonylamino)-10-norpinan-3-yl]hept-5- enoic acid)], using various allergic inflammation guinea pig models. " 08/01/2001 - "Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751." 09/01/2009 - "The aim of this study was to test the hypothesis that the prostanoid DP1 receptor contributes to asthma pathophysiology by determining the efficacy of an orally active antagonist for this receptor, S-5751, on allergen-induced bronchoconstriction, airway hyperresponsiveness (AHR) and cellular inflammation in the sheep model of asthma. "
2.	Asthma (Bronchial Asthma) 09/01/2011 - "We have previously shown that an orally active prostanoid DP receptor antagonist, S-5751, had potent anti-inflammatory effects in guinea pig and sheep asthma models. " 08/01/2001 - "In addition, S-5751 alleviated allergen-induced plasma exudation in the conjunctiva in an allergic conjunctivitis model and antigen-induced eosinophil infiltration into the lung in an asthma model. " 09/01/2009 - "The aim of this study was to test the hypothesis that the prostanoid DP1 receptor contributes to asthma pathophysiology by determining the efficacy of an orally active antagonist for this receptor, S-5751, on allergen-induced bronchoconstriction, airway hyperresponsiveness (AHR) and cellular inflammation in the sheep model of asthma. "
3.	Respiratory Hypersensitivity 09/01/2009 - "The aim of this study was to test the hypothesis that the prostanoid DP1 receptor contributes to asthma pathophysiology by determining the efficacy of an orally active antagonist for this receptor, S-5751, on allergen-induced bronchoconstriction, airway hyperresponsiveness (AHR) and cellular inflammation in the sheep model of asthma. "
4.	Nasal Obstruction 08/01/2001 - "In allergic rhinitis models, oral administration of S-5751 dramatically inhibited not only early nasal responses, as assessed by sneezing, mucosal plasma exudation, and nasal blockage, but also late responses such as mucosal plasma exudation and eosinophil infiltration. " 01/14/2008 - "S-5751 ((Z)-7-[(1R,2R,3S,5S)-2-(5-hydroxybenzo[b]thiophen-3-ylcarbonylamino)-10-norpinan-3-yl]hept-5-enoic acid), a prostanoid DP receptor antagonist, inhibited not only PGD(2)-induced nasal blockage but also nasal hyperresponsiveness to histamine and U-46619 in sensitized guinea pigs. "
5.	Allergic Rhinitis 08/01/2001 - "In allergic rhinitis models, oral administration of S-5751 dramatically inhibited not only early nasal responses, as assessed by sneezing, mucosal plasma exudation, and nasal blockage, but also late responses such as mucosal plasma exudation and eosinophil infiltration. "

Related Drugs and Biologics

1.	Prostaglandins
2.	Allergens
3.	Acids
4.	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
5.	Prostaglandin Receptors (Prostaglandin Receptor)
6.	Prednisolone (Predate)
7.	Histamine (Histamine Dihydrochloride)
8.	Antigens

Related Therapies and Procedures

1.	Oral Administration