superoxide dismutase 2

Also Known As:

SOD2 protein; SOD2 protein, human; Sod2 protein, mouse; Sod2 protein, rat; superoxide dismutase 2, C elegans; superoxide dismutase 2, mitochondrial, human; superoxide dismutase 2, mitochondrial, rat; superoxide dismutase 2, mouse; superoxide dismutase-2

Networked: 300 relevant articles (14 outcomes, 29 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Superoxide Dismutase: 11100
      - superoxide dismutase 2: 300

Experts

1.	Yao, Paul: 4 articles (01/2022 - 11/2019)
2.	Termini, Lara: 4 articles (05/2021 - 01/2011)
3.	Archer, Stephen L: 4 articles (01/2016 - 06/2010)
4.	Oniki, Kentaro: 4 articles (01/2014 - 03/2012)
5.	Saruwatari, Junji: 4 articles (01/2014 - 03/2012)
6.	Amouyel, Philippe: 3 articles (04/2022 - 11/2017)
7.	Beseme, Olivia: 3 articles (04/2022 - 11/2017)
8.	Chwastyniak, Maggy: 3 articles (04/2022 - 11/2017)
9.	Dubois-Deruy, Emilie: 3 articles (04/2022 - 11/2017)
10.	Mulder, Paul: 3 articles (04/2022 - 11/2017)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 06/20/2007 - "Mice lacking superoxide dismutase 2 (SOD2) die within the first week of life, and develop a complex heterogeneous phenotype arising from mitochondrial dysfunction and oxidative stress. " 09/01/2004 - "Hence, we have used Q-PCR to systematically assess microarray accuracy as a function of signal strength in a mouse model of mitochondrial disease, the superoxide dismutase 2 (SOD2) nullizygous mouse. " 02/02/1999 - "Mitochondrial disease in superoxide dismutase 2 mutant mice." 01/01/2022 - "Superoxide dismutase 2 ameliorates mitochondrial dysfunction in skin fibroblasts of Leber's hereditary optic neuropathy patients." 02/01/2013 - "Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2."
2.	Hyperglycemia 11/19/2019 - "Maternal diabetes induces autism-like behavior by hyperglycemia-mediated persistent oxidative stress and suppression of superoxide dismutase 2." 11/19/2019 - "The results of in vitro study showed that transient hyperglycemia induces persistent reactive oxygen species (ROS) generation with suppressed superoxide dismutase 2 (SOD2) expression. " 01/01/2022 - "Our in vitro study in human neural progenitor cells shows that transient hyperglycemia induces persistent RORA suppression through oxidative stress-mediated epigenetic modifications and subsequent dissociation of octamer-binding transcription factor 3/4 from the RORA promoter, subsequently suppressing the expression of aromatase and superoxide dismutase 2. The in vivo mouse study shows that prenatal RORA deficiency in neuron-specific RORA null mice mimics maternal diabetes-mediated ALB; postnatal RORA expression in the amygdala ameliorates, while postnatal RORA knockdown mimics, maternal diabetes-mediated ALB in offspring. "
3.	Neoplasms (Cancer) 09/01/2021 - "We identified genes associated with superoxide dismutase 2 (SOD2) and nuclear factor erythroid-2-related factor 2 (NRF2) from gene-expression data of The Cancer Genome Atlas (TCGA) by calculating Pearson correlation. " 01/01/2021 - "Furthermore, Superoxide Dismutase 2 (SOD2) in lightcyan module was proved to correlated with neutrophils infiltration in various cancer types. " 12/01/2019 - "Mitochondrial superoxide dismutase 2 mediates γ-irradiation-induced cancer cell invasion." 01/01/2018 - "Our results indicate that tumor tissue has greater total protein carbonylation, lower SOD1 and SOD2 protein levels, lower total SOD activity, and higher LC3-II levels compared to adjacent healthy tissue. " 01/01/2016 - "Mechanistically, PINK1 suppresses ROS and tumor growth through FOXO3a, a master regulator of oxidative stress and superoxide dismutase 2. These findings highlight the importance of PINK1 and ROS balance in normal and tumor cells. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/31/2017 - "This study investigated whether radiation-induced overexpression of superoxide dismutase 2 (SOD2) exerts radio-sensitizing effects on tumor cells while having radio-protective effects on normal cells during radio-activated gene therapy for human colorectal cancer. " 10/01/2008 - "Antisense oligodeoxynucleotides to human superoxide dismutase 2 and/or ectopic bcl-2 overexpression avoided polyphenols and chemoradiotherapy-induced colorectal cancer elimination and showed that the mangano-type superoxide dismutase and Bcl-2 are key targets in the molecular mechanism activated by the combined application of t-PTER and QUER."
5.	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 10/21/2022 - "Moreover, NR restored SIRT3 activity, as shown by the reduction of the acetylation of optic atrophy 1 (OPA1) and superoxide dismutase 2 (SOD2), which resulted in improved mitochondrial morphology and protection against oxidative damage in mice born to mothers fed the LP diet. " 01/01/2020 - "optic atrophy 1, peroxisome proliferator-activated receptor γ coactivator-1α, NADH:ubiquinone oxidoreductase core subunit S1/S3, and superoxide dismutase 2) were selectively lower in female HFrEF patients. " 09/15/2009 - "Ninety-eight SNPs were selected to tag the common genetic variation in nine genes, namely OPTN (optineurin), RDX (radixin), SNX16 (sorting nexin 16), OPA1 (optic atrophy 1), MFN1 (mitofusin 1), MFN2 (mitofusin 2), PARL (presenilin associated, rhomboid-like), SOD2 (superoxide dismutase 2, mitochondrial) and CYP1B1 (cytochrome P450, family 1, subfamily B, polypeptide 1). "

Related Drugs and Biologics

1.	Catalase
2.	Enzymes
3.	Proteins (Proteins, Gene)
4.	Antioxidants
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Messenger RNA (mRNA)
7.	Sirtuin 3
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Interleukin-6 (Interleukin 6)
10.	Interleukin-10 (Interleukin 10)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Chemoradiotherapy
3.	Radiotherapy
4.	Bariatric Surgery
5.	Neoadjuvant Therapy