5- bromo- N- (1- ethyl- 4- methylhexahydro- 1H- 1,4- diazepin- 6- yl)- 2- methoxy- 6- methylamino- 3- pyridinecarboxamide 2-fumarate
also a serotonin 5-HT(3) receptor antagonist; structure in first source
Also Known As:
AS-8112; AS8112
Networked: 2
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
Related Diseases
| 1. | Vomiting
05/01/2001
- " Moreover, oral administration of AS-8112 significantly inhibited emesis induced by these emetogens. " 11/23/2001
- " In addition, AS-8112 (10 microg/kg, i.c.v.) significantly inhibited emesis induced by cisplatin. " 11/23/2001
- " Intracerebroventricularly administered AS-8112 dose dependently inhibited R(+)-7-OH-DPAT (R(+)-7-hydroxy-2-(N,N-di-n-propylamino) tetraline)-induced emesis (ID(50); 0.11 microg/kg, i.c.v.). " 05/01/2001
- " AS-8112 (0.3 mg kg(-1) i.v.) significantly inhibited emesis induced by cyclophosphamide and doxorubicin. " 05/01/2001
- " In ferrets or dogs, AS-8112 dose-dependently inhibited emesis induced by R(+)-7-OH-DPAT, apomorphine, morphine or cisplatin with ID50 values of 2.22 microg kg(-1) s.c., 10.5 microg kg(-1) s.c., 14.2 microg kg(-1) i.v. and 17.6 microg kg(-1) i.v., respectively. "
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