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RG 1503

structure in first source

Also Known As:

RG1503

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - RG 1503: 2

Experts

1.	Baroukh, B: 1 article (12/2006)
2.	Barritault, D: 1 article (12/2006)
3.	Caruelle, J-P: 1 article (12/2006)
4.	Colombier, M-L: 1 article (12/2006)
5.	Escartin, Q: 1 article (12/2006)
6.	Lallam-Laroye, C: 1 article (12/2006)
7.	Saffar, J-L: 1 article (12/2006)
8.	Zlowodzki, A-S: 1 article (12/2006)
9.	Baroukh, Brigitte: 1 article (02/2004)
10.	Barritault, Denis: 1 article (02/2004)

Related Diseases

1.	Mucositis 02/01/2004 - "RG1503 given with cancer treatment might protect patients from mucositis." 02/01/2004 - "These data indicate that mucositis lesions are related to massive release of proteolytic enzymes and are improved by RG1503 treatment, this effect being ascribable in part to restoration of the MMP-TIMP balance. " 02/01/2004 - "In this study, mucositis induced in hamsters by 5-fluorouracil (5-FU) was observed after cheek-pouch scarifications, with and without administration of RGTA (RG1503), a polymer engineered to mimic the protective effects of heparan sulfate. "
2.	Periodontitis 12/01/2006 - "Periodontitis was induced in hamsters and, starting 8 weeks later, injected RG1503, a glycosaminoglycan synthesized from a 40 kDa dextran behaving like a heparan sulfate mimetic (1.5 mg kg(-1) w(-1)) or saline for 8 weeks. "
3.	Neoplasms (Cancer) 02/01/2004 - "RG1503 given with cancer treatment might protect patients from mucositis."
4.	Inflammation (Inflammations) 12/01/2006 - "These results demonstrate that RG1503 reverses the degenerative changes induced by inflammation and favors the conditions of a regenerative process. "
5.	Body Weight (Weight, Body) 02/01/2004 - "RG1503 had no effects on 5-FU-induced decreases in body weight, blood cell counts, or cheek-pouch and jejunum epithelium proliferation rates, suggesting absence of interference with the cytotoxic effects of 5-FU. "

Related Drugs and Biologics

1.	Heparitin Sulfate (Heparan Sulfate)
2.	Polymers
3.	Fluorouracil (Carac)
4.	Matrix Metalloproteinases (MMPs)
5.	Peptide Hydrolases (Proteases)
6.	Glycosaminoglycans
7.	Dextrans (Dextran)