Signaling Lymphocytic Activation Molecule Family

Type-I membrane glycoproteins that are expressed primarily on the surface of CD4 or CD8-positive T-CELLS; NATURAL KILLER CELLS; and some populations of B CELLS. They are characterized by an N-terminal, extracellular IMMUNOGLOBULIN-LIKE DOMAIN and a membrane-proximal IMMUNOGLOBULIN C2-SET DOMAIN. SLAMF receptors typically signal through homophilic interactions and are important for mediating the immune response and immune cell differentiation.

Also Known As:

SLAM Family Receptors; SLAMF Receptors; Signaling Lymphocytic Activation Molecule Family Receptors; Signaling Lymphocytic Activation Molecule Receptors; Signaling Lymphocytic Activation Molecules

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Signaling Lymphocytic Activation Molecule Family: 39
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Glycoproteins: 24834
    - Membrane Glycoproteins: 2252
      - Signaling Lymphocytic Activation Molecule Family: 39
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Signaling Lymphocytic Activation Molecule Family: 39
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Signaling Lymphocytic Activation Molecule Family: 39

human SLAMF8 protein

Bio-Agent Context: Research Results