desmuslin (synemin)

binds both desmin and alpha-dystrobrevin; GenBank AF359284

Also Known As:

synemin; DMN protein, human; Dmn protein, Drosophila; Dmn protein, mouse; Dmn protein, rat; alpha-synemin, human; beta-synemin, human; desmuslin protein, human; desmuslin protein, mouse; desmuslin protein, rat

Networked: 30 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Polymers: 13051
  - Biopolymers: 773
    - Intermediate Filament Proteins: 288
      - desmuslin: 30
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoskeletal Proteins: 739
    - Intermediate Filament Proteins: 288
      - desmuslin: 30

Experts

1.	Skalli, Omar: 9 articles (01/2016 - 04/2005)
2.	Pekny, Milos: 4 articles (01/2014 - 04/2007)
3.	Jing, Runfeng: 4 articles (09/2008 - 04/2005)
4.	Li, Zhenlin: 3 articles (01/2020 - 07/2003)
5.	Paulin, Denise: 3 articles (01/2020 - 07/2003)
6.	Paul, Madhumita: 3 articles (01/2016 - 04/2012)
7.	Wilhelmsson, Ulrika: 3 articles (01/2014 - 04/2007)
8.	Cheng, Chiung-Chi: 3 articles (01/2011 - 01/2004)
9.	Ho, Chin-Chin: 3 articles (01/2011 - 01/2004)
10.	Lai, Yih-Shyong: 3 articles (01/2011 - 01/2004)

Related Diseases

1.	Muscular Diseases (Myopathy) 01/01/2020 - "Synemin-related skeletal and cardiac myopathies: an overview of pathogenic variants." 01/01/2018 - "In murine skeletal muscle, the absence of synemin causes a mild myopathy. " 01/01/2001 - "The desmuslin gene was screened for mutations in 71 patients with various forms of myopathy for which there was no known cause. " 01/01/2001 - "As a muscle-specific intermediate filament protein, desmuslin is also a candidate for myopathies of unknown etiology. " 11/22/2023 - "A number of genetic variants in the SYNM gene encoding for the intermediate filament synemin have been reported in patients with cardiomyopathies, skeletal myopathies, cancer and certain neurodegenerative disorders. "
2.	Varicose Veins (Varicose Vein) 09/01/2010 - "Decreased desmuslin expression may affect differentiation of VSMCs and ultimately contribute to the development of varicose veins." 09/01/2010 - "Previous study indicated desmuslin, an intermediate filament protein, was differentially expressed in smooth muscle cells (SMCs) isolated from varicose veins; thus, it was naturally hypothesized that altered desmuslin expression might in turn affect the functioning of VSMCs, leading to the phenotypic alterations and varicose vein development. " 10/01/2022 - "The intermediate filament protein synemin (SYN) is reported to modulate phenotypic alterations and varicose vein development, but there is little understanding of its exact functions in CHD-PAH. "
3.	Oculopharyngeal Muscular Dystrophy 07/01/2003 - "In the present study, the distribution of synemin was examined using immunohistochemistry in muscle biopsy specimens from patients suffering from myofibrillar myopathy (MM, n=6), dermatomyositis (DM, n=3), inclusion body myositis (IBM, n=5), oculopharyngeal muscular dystrophy (OPD, n=3) and denervation atrophy (DA, n=3), to investigate the possible participation of this protein in the pathogenesis of various muscular diseases. "
4.	Inclusion Body Myositis 07/01/2003 - "In the present study, the distribution of synemin was examined using immunohistochemistry in muscle biopsy specimens from patients suffering from myofibrillar myopathy (MM, n=6), dermatomyositis (DM, n=3), inclusion body myositis (IBM, n=5), oculopharyngeal muscular dystrophy (OPD, n=3) and denervation atrophy (DA, n=3), to investigate the possible participation of this protein in the pathogenesis of various muscular diseases. "
5.	Dermatomyositis (Dermatopolymyositis) 07/01/2003 - "In the present study, the distribution of synemin was examined using immunohistochemistry in muscle biopsy specimens from patients suffering from myofibrillar myopathy (MM, n=6), dermatomyositis (DM, n=3), inclusion body myositis (IBM, n=5), oculopharyngeal muscular dystrophy (OPD, n=3) and denervation atrophy (DA, n=3), to investigate the possible participation of this protein in the pathogenesis of various muscular diseases. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Nestin
3.	Vimentin
4.	Glial Fibrillary Acidic Protein
5.	Desmin
6.	Actinin
7.	desmuslin (synemin)
8.	Claudin-1
9.	Transcription Factor 3
10.	Protein Phosphatase 2 (Protein Phosphatase 2A)

Related Therapies and Procedures

1.	Denervation
2.	Cell- and Tissue-Based Therapy (Cell Therapy)