ambuic acid

a highly functionalized cyclohexenone, isolated from Pestalotiopsis sp. and Monochaetia sp.; structure in first source

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

1.	Inflammation (Inflammations) 08/01/2018 - "The aim of the present study was to investigate the inhibitory effect of ambuic acid on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 macrophages. "
2.	Neoplasms (Cancer) 11/01/2023 - "Retracted: Isolation and purifications of an ambuic acid derivative compound from marine algal endophytic fungi Talaromyces flavus that induces apoptosis in MDA-MB-231 cancer cells."
3.	Infections 01/01/2017 - "Signal Biosynthesis Inhibition with Ambuic Acid as a Strategy To Target Antibiotic-Resistant Infections."
4.	Breast Neoplasms (Breast Cancer) 11/01/2023 - "The ambuic acid derivative compound showed potent cytotoxicity on MDA-MB-231 (breast cancer cells) with an IC50 value of 26 μM and induced apoptosis in the MDA-MB-231 cells in a time-dependent and reactive oxygen species-independent manner."
5.	Abscess 01/01/2017 - "We show that a 5-μg dose of ambuic acid reduces MRSA-induced abscess formation in a mouse model and verify its quorum sensing inhibitory activity in vivo Finally, we employed mass spectrometry to identify or confirm the structure of quorum sensing signaling peptides in three strains each of S. "

1.	Lipopolysaccharides
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Peptides (Polypeptides)
4.	Anti-Bacterial Agents (Antibiotics)