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linderol A

a hexahydrodibenzofuran isolated from Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cell; structure in first source
Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ohta, Shunsaku: 2 articles (07/2007 - 02/2003)
2. Kawasaki, Ikuo: 2 articles (07/2007 - 02/2003)
3. Yamashita, Masayuki: 2 articles (07/2007 - 02/2003)
4. Murai, Kousuke: 1 article (07/2007)
5. Miyatake, Akemi: 1 article (07/2007)
6. Yadav, Navnath Dnyanoba: 1 article (07/2007)
7. Takahara, Ayano: 1 article (07/2007)
8. Kurume, Ai: 1 article (07/2007)
9. Sawaki, Takeshi: 1 article (07/2007)
10. Sugimoto, Yasuko: 1 article (07/2007)

Related Diseases

1. Melanoma (Melanoma, Malignant)
02/21/2003 - "First total synthesis of (+/-)-Linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells."
05/03/2001 - "[reaction in text] The first total synthesis of (+/-)-linderol A, a hexahydrodibenzofuran isolated from Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells was achieved via a 20-step of reaction in 7.64% overall yield starting from 4,6-dimethoxysalicylaldehyde."
05/03/2001 - "The first total synthesis of (+/-)-linderol A, a tricyclic hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells."
07/20/2007 - "The first asymmetric total synthesis of (-)-Linderol A, a potent inhibitor of melanin biosynthesis of cultured B-16 melanoma cells, has been achieved via two key reactions: a diastereoselective [2+2] photocycloaddition of a coumarin-3-carboxylate bearing a chiral auxiliary with 3-methyl-1-butene and a subsequent stereoconvergent transformation of the photoadducts with use of dimethylsulfoxonium methylide to afford a tetrahydrodibenzofuran derivative."
02/21/2003 - "The first total synthesis of (+/-)-Linderol A, a hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on the melanin biosynthesis of cultured B-16 melanoma cells, was achieved through 19 steps of reaction in 6.6% overall yield, in which the critical step was a tandem reaction of a 3-ethoxycarbonylcoumarin derivative with dimethylsulfoxonium methylide to yield the 2-ethoxycarbonylcyclopenta[b]benzofuran-3-ol derivative."

Related Drugs and Biologics

1. Melanins (Melanin)
2. benzofuran
3. coumarin-3-carboxylic acid