lebein

01/01/2016 - "Therefore, we propose Lebein as a new candidate for development of potential therapies for melanoma."
01/01/2016 - "Melanoma cells became detached but were less invasive with upregulation of E-cadherin after Lebein exposure. "
01/01/2016 - "In this study, we showed that Lebein blocks melanoma cell proliferation and induces a more differentiated phenotype with inhibition of extracellular signal-regulated kinase (ERK) phosphorylation and microphthalmia-associated transcription factor (MITF) overexpression. "
01/01/2016 - "Anti-neoplasic properties have been highlighted for different disintegrins from snake venom including Lebein; however, the exact effect of Lebein on melanoma has not yet been defined. "
01/01/2016 - "Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells."

01/01/2017 - "In this study, we investigated the effect of Lebein on the p53-dependent growth of human colon adenocarcinoma cell lines. "
01/01/2017 - "Interestingly, Lebein-induced apoptosis of colon cancer cells was dependent on their p53 status. "
01/01/2017 - "Overall, our work indicates that Lebein may be useful to design a new therapy against colon cancer. "
01/01/2017 - "Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression."
01/01/2017 - "We found that Lebein significantly inhibited LS174 (p53wt), HCT116 (p53wt), and HT29 (p53mut) colon cancer cell viability by inducing cell cycle arrest through the modulation of expression levels of the tumor suppression factor p53, cell cycle regulating proteins cyclin D1, CDK2, CDK4, retinoblastoma (Rb), CDK1, and cyclin-dependent kinase inhibitors p21 and p27. "

01/01/2017 - "We found that Lebein significantly inhibited LS174 (p53wt), HCT116 (p53wt), and HT29 (p53mut) colon cancer cell viability by inducing cell cycle arrest through the modulation of expression levels of the tumor suppression factor p53, cell cycle regulating proteins cyclin D1, CDK2, CDK4, retinoblastoma (Rb), CDK1, and cyclin-dependent kinase inhibitors p21 and p27. "

01/01/2017 - "Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression."
01/01/2017 - "We found that Lebein significantly inhibited LS174 (p53wt), HCT116 (p53wt), and HT29 (p53mut) colon cancer cell viability by inducing cell cycle arrest through the modulation of expression levels of the tumor suppression factor p53, cell cycle regulating proteins cyclin D1, CDK2, CDK4, retinoblastoma (Rb), CDK1, and cyclin-dependent kinase inhibitors p21 and p27. "