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salacinol

a sulfated thiosugar from Salacia reticulata (CELASTRACEAE); structure in first source

Also Known As:

neosalacinol

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Sugar Alcohols: 143
    - salacinol: 6
Carbohydrates: 22023
- Sugar Alcohols: 143
  - salacinol: 6
Inorganic Chemicals: 9
- Electrolytes: 16106
  - Ions: 7857
    - Anions: 3501
      - Sulfates: 2753
        salacinol: 6
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfuric Acids: 4
      - Sulfates: 2753
        salacinol: 6

Experts

1.	Muraoka, Osamu: 2 articles (02/2015 - 04/2009)
2.	Tanabe, Genzoh: 2 articles (02/2015 - 04/2009)
3.	Yoshikawa, Masayuki: 2 articles (02/2015 - 04/2009)
4.	Bello, N T: 1 article (07/2021)
5.	Hao, L: 1 article (07/2021)
6.	Kreitman, A: 1 article (07/2021)
7.	Schlussel, Y: 1 article (07/2021)
8.	Schneider, S H: 1 article (07/2021)
9.	Shapses, S A: 1 article (07/2021)
10.	Ferkous, Fouad: 1 article (02/2018)

Related Diseases

1.	Bone Resorption 07/01/2021 - "In this study, a salacinol-type α-GI increased GLP-1 and markedly reduced postprandial bone resorption compared to placebo, suggesting it could have implications for bone health. "
2.	Type 2 Diabetes Mellitus (MODY) 02/27/2015 - "Salacinol and related analogs: new leads for type 2 diabetes therapeutic candidates from the Thai traditional natural medicine Salacia chinensis." 02/01/2018 - "The outcome of this investigation sheds light on the molecular characteristics of the binding of salacinol analogues to nt-MGAM enzyme and identifies new possible inhibitors which have the potential to be developed into drugs, thus significantly contributing to the design and optimization of therapeutic strategies against type 2 diabetes." 02/03/2006 - "Three of the chain-extended homologues inhibited recombinant human maltase glucoamylase, one of the key intestinal enzymes involved in the breakdown of glucose oligosaccharides in the small intestine, with Ki values in the low micromolar range, of approximately the same magnitude as salacinol, thus providing lead candidates for the treatment of Type 2 diabetes."
3.	Weight Gain 06/01/2003 - "Rats consuming salacinol extract had reduced (P <0.05) weight gain and feed intake. "
4.	Confusion (Bewilderment) 04/15/2009 - "Discrepancies and confusion in the literature concerning the NMR spectroscopic properties of salacinol (1) have also been clarified."
5.	Body Weight (Weight, Body) 06/01/2003 - "The relative (% of body weight) testicular weight was higher (P<0.05) for rats consuming salacinol extract, whereas, the relative liver and spleen weight was lower (P<0.05) for rats consuming salacinol extract. "

Related Drugs and Biologics

1.	Glucagon-Like Peptide 1 (GLP 1)
2.	Enzymes
3.	Oligosaccharides
4.	Glucose (Dextrose)
5.	alpha-Glucosidases (Acid Maltase)